Recombinant HSV1 gG Envelope Protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HSV1 gG envelope protein also known as glycoprotein G is an important part of the Herpes Simplex Virus 1. This protein has a molecular mass of approximately 71 kDa. It is a type I membrane protein found in the viral envelope and on the surface of infected host cells. Glycoprotein G plays a role in viral attachment and entry into the host cells helping the virus infect and propagate within the host organism.

Biological function summary

Glycoprotein G assists in the immune evasion by binding to host immune modulators reducing immune detection. Glycoprotein G is part of the larger complex involved in viral infection along with other glycoproteins such as gB gD and gH. These components work together to facilitate the fusion of the viral and host cell membranes which allows viral entry into the host cell.

Pathways

Glycoprotein G participates in the viral entry pathway and immune modulation pathways. In the viral entry pathway it interacts with other viral glycoproteins like gD which binds to host cell receptors like nectin-1. This interaction is important for the viral fusion process. The immune modulation pathway involves interference with host immune responses where glycoprotein G assists in decreasing the recognition by host antibodies.

Glycoprotein G expression relates to Herpes Simplex Virus type 1 (HSV-1) infections and complications such as herpes labialis and encephalitis. These infections can result in recurrent lesions around the oral or facial area and severe complications in neural tissues. Glycoprotein G has connections to other viral proteins like glycoprotein B and D through its role in initiating viral infections contributing to disease progression and symptom manifestations.