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AB43036

Recombinant HTLV I p24 protein

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Recombinant HTLV I p24 protein is a Human T-cell lymphotrophic virus type 1 (Caribbean isolate) Full Length protein, in the 314 to 344 aa range, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.

View Alternative Names

Gag polyprotein, Pr53Gag, gag, CA, p24, Capsid protein p24

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

WB, ELISA

applications

Biologically active

No

Accession

P14076

Animal free

No

Carrier free

No

Species

Human T-cell lymphotrophic virus type 1 (Caribbean isolate)

Storage buffer

pH: 6 Constituents: 0.82% Sodium phosphate, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

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Complementary Products

Reagents, Controls & Accessories

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Primary Antibodies

AB32352

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Assay Kits

AB218268

HIV1 p24 ELISA Kit

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Secondary Antibodies

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Proteins & Peptides

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":344,"aminoAcidStart":314,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P14076","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HTLV I p24 also known as the core protein p24 of human T-cell leukemia virus type 1 (HTLV-1) is an integral component of the virus's capsid. With an approximate molecular mass of 24 kilodaltons p24 is vital for the assembly and stability of the viral capsid structure. It helps encapsulate the viral RNA genome ensuring the protection and integrity of the genetic material during viral replication. HTLV I p24 is primarily expressed in HTLV-1-infected host cells where it plays a pivotal role in the virus's life cycle and transmission.
Biological function summary

The p24 protein functions as part of the Gag polyprotein a precursor that is cleaved to form several components of the viral particle including matrix capsid and nucleocapsid proteins. This protein is considered essential for the maturation process of the virus enabling the virus to become infectious. It contributes to the formation of the mature viral core which requires precise cleavage of the Gag polyprotein. This cleavage allows the virus to effectively infect host cells and propagate within an organism.

Pathways

The HTLV I p24 protein interacts significantly in the viral replication and assembly pathways. It is involved in the virion assembly pathway which is important for generating new infectious viral particles. Key interactions within these pathways include related proteins such as matrix and nucleocapsid proteins also derived from the Gag polyprotein. These components collectively facilitate the budding process from the host cell membrane leading to the release of virions that can infect new cells.

HTLV I p24 has strong associations with adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The expression of p24 in infected T cells can promote oncogenic pathways contributing to the clonal proliferation of malignant T cells in ATLL. During the course of these diseases proteins such as Tax another HTLV-1 accessory protein interact with p24 further influencing the pathogenesis and progression of HTLV-1-related disorders. Understanding these interactions brings insights into potential therapeutic targets for HTLV-1-associated diseases.
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Specifications

Form

Liquid

Additional notes

Organic extraction > S-300 > HPLC.

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General info

Function

Gag polyprotein. The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.. Matrix protein p19. Matrix protein.. Capsid protein p24. Forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.. Nucleocapsid protein p15-gag. Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.

Post-translational modifications

Gag polyprotein. Specific enzymatic cleavages by the viral protease yield mature proteins. The polyprotein is cleaved during and after budding, this process is termed maturation.. Matrix protein p19. Phosphorylation of the matrix protein p19 by MAPK1 seems to play a role in budding.. Gag polyprotein. Ubiquitinated by host NEDD4.. Gag polyprotein. Myristoylated. Myristoylation of the matrix (MA) domain mediates the transport and binding of Gag polyproteins to the host plasma membrane and is required for the assembly of viral particles.

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Product protocols

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Target data

Gag polyprotein. The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.. Matrix protein p19. Matrix protein.. Capsid protein p24. Forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.. Nucleocapsid protein p15-gag. Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.
See full target information gag

Additional targets

HTLV I p24
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