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AB153343

Recombinant Human 24p3R protein (GST tag N-Terminus)

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Recombinant Human 24p3R protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 538 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

BOCT, BOIT, SLC22A17, Solute carrier family 22 member 17, 24p3 receptor, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor, 24p3R, NgalR

1 Images
SDS-PAGE - Recombinant Human 24p3R protein (GST tag N-Terminus) (AB153343)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human 24p3R protein (GST tag N-Terminus) (AB153343)

ab153343 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q8WUG5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB237539

Anti-24p3R antibody

Immunocytochemistry/ Immunofluorescence - Anti-24p3R antibody (AB237539)

  • 0
  • 0
Proteins & Peptides

AB187960

Lipocalin-2 / NGAL peptide

  • 0
  • 0
Primary Antibodies

AB125075

Anti-Lipocalin-2 / NGAL antibody [EPR5084]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Lipocalin-2 / NGAL antibody [EPR5084] (AB125075)

  • 5
  • 1
Assay Kits

AB199083

Mouse Lipocalin-2 ELISA Kit (NGAL)

Recombinant|SimpleStep

ELISA - Mouse Lipocalin-2 ELISA Kit (NGAL) (AB199083)

  • 5
  • 2
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTRCDHVPLLATPNPAL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":538,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8WUG5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 24p3R also known as SLC22A17 or neutrophil gelatinase-associated lipocalin receptor is a receptor protein that facilitates cellular uptake of its ligand the neutrophil gelatinase-associated lipocalin (NGAL) known scientifically as lipocalin-2. This receptor with a molecular mass of approximately 55 kDa participates in iron regulation by binding and internalizing iron-laden NGAL. Expression of 24p3R occurs across various tissues with significant presence in kidney liver and spleen reflecting its systemic role in iron homeostasis.
Biological function summary

The NGAL and 24p3R interaction plays a critical role in iron metabolism and immune response. The receptor delivers NGAL-bound iron to cells impacting the cell's iron availability an essential process for many cellular functions and maintaining systemic iron balance. This interaction does not occur in isolation; 24p3R operates within a larger complex network involving other iron-regulating proteins like transferrin which collectively orchestrate iron absorption distribution and storage in the body.

Pathways

24p3R functions within the iron metabolism pathway essential for iron uptake and regulation. Its interaction with NGAL is related to the transferrin receptor pathway which regulates iron uptake through transferrin-bound iron. These interactions highlight the role of 24p3R beyond the basic cellular uptake of NGAL influencing systemic iron distribution and maintaining cellular iron homeostasis. Proteins like transferrin family members modulate this pathway and are integral to the function of 24p3R in cellular iron control.

24p3R involvement is directly linked to conditions characterized by iron imbalance such as iron deficiency anemia and chronic kidney disease. Aberrant expression or function of 24p3R can contribute to these diseases through disturbed iron metabolism. In these contexts NGAL levels often elevated act as markers of disrupted iron homeostasis and inflammation further associating 24p3R with the pathological processes. By connecting with NGAL 24p3R plays a role in these diseases highlighting its importance in maintaining iron equilibrium in health and disease.
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Specifications

Form

Liquid

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General info

Function

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

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Product protocols

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Target data

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
See full target information SLC22A17
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Product promise

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