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AB114804

Recombinant Human 5-HT-5A protein

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Recombinant Human 5-HT-5A protein is a Human Full Length protein, in the 1 to 357 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

5-hydroxytryptamine receptor 5A, 5-HT-5, 5-HT-5A, 5-HT5A, Serotonin receptor 5A, HTR5A

1 Images
SDS-PAGE - Recombinant Human 5-HT-5A protein (AB114804)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human 5-HT-5A protein (AB114804)

ab114804 on 12.5% SDS-PAGE Stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

P47898

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>(Recombinant protein).</p>" } } }
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Sequence info

[{"sequence":"MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH","proteinLength":"Full Length","predictedMolecularWeight":"65.34 kDa","actualMolecularWeight":null,"aminoAcidEnd":357,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P47898","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 5-HT-5A receptor also known as serotonin receptor 5A or HTR5A is a G protein-coupled receptor (GPCR). It has a mass of approximately 41 kDa. This receptor is a part of the serotonin receptor family which responds to the neurotransmitter serotonin. 5-HT-5A is expressed in various regions of the brain including the cortex hippocampus and cerebellum. Its role is associated with modulating neurotransmission and influencing numerous neurological processes.
Biological function summary

The 5-HT-5A receptor acts as a modulatory component within the central nervous system. It influences the release of neurotransmitters and has a role in regulating mood cognition and circadian rhythm. While 5-HT-5A is not part of a larger complex it functions by coupling with inhibitory G proteins often leading to a decrease in cyclic AMP levels inside neurons. By affecting the intracellular signaling cascades 5-HT-5A impacts various physiological responses related to serotonin.

Pathways

The 5-HT-5A receptor plays a significant role in the serotonin signaling pathway. It is involved in the modulation of downstream targets that are important for mood regulation and neuroendocrine control. The receptor also interacts with other proteins in the serotonin pathway such as the 5-HT-1A receptor collectively contributing to the comprehensive effects of serotonin in the nervous system. These pathways highlight the receptor's involvement in homeostatic processes and neurotransmitter balance.

The 5-HT-5A receptor's function relates to conditions like depression and sleep disorders including insomnia. Altered 5-HT-5A function or expression has been observed in these disorders suggesting its involvement in their pathophysiology. Furthermore the receptor's interaction with proteins like the serotonin transporter (SERT) indicates its influence on serotonin reuptake and points to complex regulatory mechanisms associated with psychiatric conditions. Such connections underline the importance of studying 5-HT-5A in therapeutic contexts.
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Specifications

Form

Liquid

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General info

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed : 35610220, PubMed : 35835867, PubMed : 9865521). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (PubMed : 35835867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed : 35610220, PubMed : 35835867, PubMed : 9865521). HTR5A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission : signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed : 35610220, PubMed : 35835867, PubMed : 9865521).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed : 35610220, PubMed : 35835867, PubMed : 9865521). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (PubMed : 35835867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed : 35610220, PubMed : 35835867, PubMed : 9865521). HTR5A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission : signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed : 35610220, PubMed : 35835867, PubMed : 9865521).
See full target information 5-hydroxytryptamine receptor 5A
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