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AB132419

Recombinant Human 5HT1A Receptor protein (GST tag N-Terminus)

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(1 Review)

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(0 Publication)

Recombinant Human 5HT1A Receptor protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 422 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

ADRB2RL1, ADRBRL1, HTR1A, 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, G-21, Serotonin receptor 1A

1 Images
SDS-PAGE - Recombinant Human 5HT1A Receptor protein (GST tag N-Terminus) (AB132419)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human 5HT1A Receptor protein (GST tag N-Terminus) (AB132419)

12.5% SDS-PAGE analysis of ab132419, stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, ELISA, WB

applications

Biologically active

No

Accession

P08908

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB307718

Anti-P2X7 antibody [EPR26989-11]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2X7 antibody [EPR26989-11] (AB307718)

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  • 0
Primary Antibodies

AB75810

Anti-GAP43 antibody [EP890Y] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Flow Cytometry (Intracellular) - Anti-GAP43 antibody [EP890Y] - Neuronal Marker (AB75810)

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Proteins & Peptides

AB114804

Recombinant Human 5-HT-5A protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human 5-HT-5A protein (GST tag N-Terminus) (AB114804)

  • 0
  • 0
Primary Antibodies

AB129103

Anti-Eph receptor B1/NET antibody [EPR6457]

RabMAb|Recombinant|Trial Size

Western blot - Anti-Eph receptor B1/NET antibody [EPR6457] (AB129103)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ","proteinLength":"Full Length","predictedMolecularWeight":"72.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":422,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P08908","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 5HT1A receptor also known as 5-HT1A or serotonin receptor 1A is part of the 5-HT receptor family. This receptor functions mechanically as a G protein-coupled receptor (GPCR) with a molecular mass of approximately 46 kDa. It is widely expressed in the brain with high concentrations in areas like the hippocampus raphe nuclei and cerebral cortex. Additionally you can find 5HT1A receptors in peripheral tissues although at lower levels. They play an essential role in mediating inhibitory neurotransmission by reducing the production of cAMP.
Biological function summary

The 5HT1A receptor is important in regulating mood anxiety and cognition. These receptors function as part of a receptor complex interacting with other serotonin receptors like 5-HT2 and 5-HT3 to modulate neural processes. The 5HT1A receptor mediates its effects by inhibiting adenylate cyclase resulting in decreased levels of intracellular cAMP. This inhibition subsequently affects ion channel function and neurotransmitter release influencing various mental and physiological processes.

Pathways

Several serotonin pathways involve the 5HT1A receptor including the serotonergic and dopaminergic pathways. These pathways are essential for healthy brain function and mood regulation. The receptor also interacts with the protein RGS10 which modulates G protein signaling. RGS10 can influence the pathways the 5HT1A receptor is involved in providing a regulatory mechanism for neurotransmission and receptor activity.

The 5HT1A receptor is linked to depression and anxiety disorders. Abnormalities in the function or expression of this receptor can result in altered serotonergic signaling contributing to these conditions. The receptor's relationship with the protein serotonergic 5-HT2A receptor can modulate the risk and progression of mood disorders. Researchers are actively investigating potential therapies that target the 5-HT1A receptor to alleviate symptoms of these mental health conditions.
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Specifications

Form

Liquid

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General info

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 22957663, PubMed : 3138543, PubMed : 33762731, PubMed : 37935376, PubMed : 37935377, PubMed : 8138923, PubMed : 8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed : 22957663, PubMed : 3138543, PubMed : 33762731, PubMed : 38552625, PubMed : 8138923, PubMed : 8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 22957663, PubMed : 3138543, PubMed : 33762731, PubMed : 8138923, PubMed : 8393041). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission : signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed : 33762731, PubMed : 35610220). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). Plays a role in the response to anxiogenic stimuli (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

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Product protocols

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Target data

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 22957663, PubMed : 3138543, PubMed : 33762731, PubMed : 37935376, PubMed : 37935377, PubMed : 8138923, PubMed : 8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed : 22957663, PubMed : 3138543, PubMed : 33762731, PubMed : 38552625, PubMed : 8138923, PubMed : 8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 22957663, PubMed : 3138543, PubMed : 33762731, PubMed : 8138923, PubMed : 8393041). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission : signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed : 33762731, PubMed : 35610220). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). Plays a role in the response to anxiogenic stimuli (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968).
See full target information HTR1A
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