Recombinant Human 67kDa Laminin Receptor protein is a Human Full Length protein, in the 1 to 295 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M S G A L D V L Q M K E E D V L K F L A A G T H L G G T N L D F Q M E Q Y I Y K R K S D G I Y I I N L K R T W E K L L L A A R A I V A I E N P A D V S V I S S R N T G Q R A V L K F A A A T G A T P I A G R F T P G T F T N Q I Q A A F R E P R L L V V T D P R A G H Q P L T E A S Y V N L P T I A L C N T D S P L R Y V D I A I P C N N K G A H S V G L M W W M L A R E V L R M R G T I S R E H P W E V M P D L Y F Y R D P E E I E K E E Q A A A E K A V T K E E F Q G E W T A P A P E F T A T Q P E V A D W S E G V Q V P S V P I Q Q F P T E D W S A Q P A T E D W S A A P T A Q A T E W V G A T T D W S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. (Microbial infection) Acts as a receptor for the Dengue virus. (Microbial infection) Acts as a receptor for the Sindbis virus. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. (Microbial infection) Acts as a receptor for the pathogenic prion protein. (Microbial infection) Acts as a receptor for bacteria.
Alternative names
LAMBR, LAMR1, RPSA, Small ribosomal subunit protein uS2, 37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 40S ribosomal protein SA, 67 kDa laminin receptor, Colon carcinoma laminin-binding protein, Laminin receptor 1, Laminin-binding protein precursor p40, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, 37LRP, LRP/LR, 67LR, LamR, LBP/p40
Recommended products
Recombinant Human 67kDa Laminin Receptor protein is a Human Full Length protein, in the 1 to 295 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P08865-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
- M S G A L D V L Q M K E E D V L K F L A A G T H L G G T N L D F Q M E Q Y I Y K R K S D G I Y I I N L K R T W E K L L L A A R A I V A I E N P A D V S V I S S R N T G Q R A V L K F A A A T G A T P I A G R F T P G T F T N Q I Q A A F R E P R L L V V T D P R A G H Q P L T E A S Y V N L P T I A L C N T D S P L R Y V D I A I P C N N K G A H S V G L M W W M L A R E V L R M R G T I S R E H P W E V M P D L Y F Y R D P E E I E K E E Q A A A E K A V T K E E F Q G E W T A P A P E F T A T Q P E V A D W S E G V Q V P S V P I Q Q F P T E D W S A Q P A T E D W S A A P T A Q A T E W V G A T T D W S
- Accession
- P08865
- Protein length
- Full Length
- Predicted molecular weight
- 58.56 kDa
- Amino acids
- 1 to 295
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.
- Sequence similarities
Belongs to the universal ribosomal protein uS2 family.
- Post-translational modifications
Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863).
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The 67kDa Laminin Receptor also known as the laminin binding protein or protein laminin functions as a receptor for laminin an important component of the extracellular matrix. This receptor is expressed in many tissue types serving an important mechanical role by mediating the adhesion and migration of cells. The receptor anchors cells to laminin molecules thereby influencing cell differentiation and proliferation. The molecular weight of the laminin receptor is approximately 67 kilodaltons which signifies it as a critical player in various cellular processes.
- Biological function summary
This receptor engages in cellular interactions that are essential for maintaining the integrity and architecture of tissues. It often associates with other proteins to form complexes which further strengthen its functional capabilities. By anchoring laminin to the cell surface it regulates cell signaling pathways that influence cell motility invasion and survival. These interactions suggest that the 67kDa Laminin Receptor's function goes beyond simple adhesion impacting cellular responsiveness to external matrix cues.
- Pathways
The receptor influences the MAPK and PI3K/Akt signaling pathways which are significant in cell survival and proliferation. Through such pathways it interacts with numerous proteins including integrins and fibronectin receptors facilitating orchestrated cell signaling. This connectivity highlights the receptor's role in cellular communication networks contributing to dynamic processes like wound healing and angiogenesis.
- Associated diseases and disorders
Aberrant expression of the 67kDa Laminin Receptor relates to conditions such as cancer and Alzheimer's disease. In cancer its overexpression links to increased tumor invasiveness likely due to enhanced cell motility mediated through integrin interactions. In Alzheimer's disease its relationship with amyloid precursor protein influences plaque formation exacerbating disease progression. Understanding these connections highlights potential therapeutic targets for disease intervention.
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1 product image
SDS-PAGE - Recombinant Human 67kDa Laminin Receptor protein (ab114294)
12.5% SDS-PAGE image showing ab114294 at approx 58.56kDa. Stained with Coomassie Blue.
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