Recombinant Human A1BG protein (His tag) is a Human Full Length protein, in the 1 to 495 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M S M L V V F L L L W G V T W G P V T E A A I F Y E T Q P S L W A E S E S L L K P L A N V T L T C Q A H L E T P D F Q L F K N G V A Q E P V H L D S P A I K H Q F L L T G D T Q G R Y R C R S G L S T G W T Q L S K L L E L T G P K S L P A P W L S M A P V S W I T P G L K T T A V C R G V L R G V T F L L R R E G D H E F L E V P E A Q E D V E A T F P V H Q P G N Y S C S Y R T D G E G A L S E P S A T V T I E E L A A P P P P V L M H H G E S S Q V L H P G N K V T L T C V A P L S G V D F Q L R R G E K E L L V P R S S T S P D R I F F H L N A V A L G D G G H Y T C R Y R L H D N Q N G W S G D S A P V E L I L S D E T L P A P E F S P E P E S G R A L R L R C L A P L E G A R F A L V R E D R G G R R V H R F Q S P A G T E A L F E L H N I S V A D S A N Y S C V Y V D L K P P F G G S A P S E R L E L H V D G P P P R P Q L R A T W S G A V L A G R D A V L R C E G P I P D V T F E L L R E G E T K A V K T V R T P G A A A N L E L I F V G P Q H A G N Y R C R Y R S W V P H T F E S E L S D P V E L L V A E S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
Alpha-1B-glycoprotein, Alpha-1-B glycoprotein, A1BG
Recommended products
Recombinant Human A1BG protein (His tag) is a Human Full Length protein, in the 1 to 495 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P04217-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M S M L V V F L L L W G V T W G P V T E A A I F Y E T Q P S L W A E S E S L L K P L A N V T L T C Q A H L E T P D F Q L F K N G V A Q E P V H L D S P A I K H Q F L L T G D T Q G R Y R C R S G L S T G W T Q L S K L L E L T G P K S L P A P W L S M A P V S W I T P G L K T T A V C R G V L R G V T F L L R R E G D H E F L E V P E A Q E D V E A T F P V H Q P G N Y S C S Y R T D G E G A L S E P S A T V T I E E L A A P P P P V L M H H G E S S Q V L H P G N K V T L T C V A P L S G V D F Q L R R G E K E L L V P R S S T S P D R I F F H L N A V A L G D G G H Y T C R Y R L H D N Q N G W S G D S A P V E L I L S D E T L P A P E F S P E P E S G R A L R L R C L A P L E G A R F A L V R E D R G G R R V H R F Q S P A G T E A L F E L H N I S V A D S A N Y S C V Y V D L K P P F G G S A P S E R L E L H V D G P P P R P Q L R A T W S G A V L A G R D A V L R C E G P I P D V T F E L L R E G E T K A V K T V R T P G A A A N L E L I F V G P Q H A G N Y R C R Y R S W V P H T F E S E L S D P V E L L V A E S
- Accession
- P04217
- Protein length
- Full Length
- Predicted molecular weight
- 53.4 kDa
- Amino acids
- 1 to 495
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
A1BG also known as alpha-1-B glycoprotein is a plasma protein with a mass of approximately 63 kDa. It demonstrates expression prominently in the liver and circulates in the bloodstream. The gene coding for A1BG is located on chromosome 19. A1BG does not seem to have enzymatic activity but instead acts as a carrier protein interacting with other molecules to modulate their stability and availability in plasma.
- Biological function summary
The function of A1BG involves interaction with cysteine proteinase inhibitors though it is not part of any known large protein complex. It participates in the regulation of protease activity by sequestering inhibitors from the active site of proteases. This regulation plays a role in maintaining balanced proteolytic activity in tissues which is important for processes such as inflammation and tissue remodeling.
- Pathways
A1BG is involved in metabolic processes of extracellular proteins. The protein does not interact directly with major signaling pathways but it influences them indirectly by modulating enzymatic activity. A1BG interacts with alpha-2-macroglobulin which is part of the protease inhibitor category and is also involved in the immune response. This relationship impacts the bioavailability and activity of various cytokines and growth factors affecting pathways like inflammation control and extracellular matrix organization.
- Associated diseases and disorders
A1BG levels show association with conditions like cancer and neurodegenerative diseases. Observed in certain cancers altered A1BG expression might influence tumor growth and metastasis. In neurodegenerative disorders such as Alzheimer's disease the protein's interaction with protease inhibitors could potentially affect amyloid-beta processing. The interaction between A1BG and alpha-2-macroglobulin is significant as dysregulation in this association may contribute to the disease pathogenesis.
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SDS-PAGE - Recombinant Human A1BG protein (His tag) (ab276701)
SDS-PAGE analysis of ab276701
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