Recombinant Human A2LD1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

A2LD1 also known as Acyl-CoA dehydrogenase (ACAD11) is a mitochondrial enzyme with a mass of approximately 79 kDa. It plays an important role in the oxidation of long-chain fatty acids. This protein is expressed in various tissues with increased expression noted in heart and skeletal muscle. As part of fatty acid metabolism A2LD1 is involved in converting fatty acyl-CoA molecules into enoyl-CoA molecules producing energy.

Biological function summary

A2LD1 assists in the breakdown of fatty acids which are a critical energy source especially during periods of fasting or high-energy demands. It functions as a part of the mitochondrial fatty acid beta-oxidation complex where it collaborates with other enzymes to effectively degrade long-chain fatty acids. This cooperative function ensures efficient energy production needed for various cellular processes.

Pathways

A2LD1 is an essential component in the mitochondrial fatty acid beta-oxidation pathway. This pathway works closely with the ketogenesis pathway to provide necessary energy sources in the form of ketone bodies during prolonged exercise or calorie restriction. A2LD1 interacts with proteins like HADHB and CPT1A which play key roles in facilitating the transport and breakdown of fatty acids within the mitochondria.

A2LD1 has been associated with disorders involving energy metabolism such as mitochondrial myopathy. This protein's dysfunction may contribute to energy shortages in muscle cells leading to muscle weakness and related symptoms. Additionally there is evidence linking alterations in A2LD1 with cardiovascular diseases as it plays a part in maintaining energy homeostasis in heart tissues. Altered activity of related proteins like ACADVL and LCAD in these pathways might exacerbate such conditions making A2LD1 an important focus for research in energy metabolism disorders.