Recombinant Human AADAC/DAC protein (Tagged)
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Recombinant Human AADAC/DAC protein (Tagged) is a Human Fragment protein, in the 24 to 399 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
DAC, AADAC, Arylacetamide deacetylase
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human AADAC/DAC protein (Tagged) (AB235022)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235022 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) AADAC/DAC.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human AADAC/DAC protein (Tagged) (AB235022)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235022 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) AADAC/DAC.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human AADAC/DAC protein (Tagged) (AB235022)
ab235022 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
AADAC plays a critical role in the metabolism of drugs and endogenous lipids. It does not form part of larger complexes but acts independently to facilitate the processing of compounds within cells. This enzymatic activity contributes to detoxification processes by altering the chemical structure of various compounds which are then excreted from the body. AADAC also influences lipid metabolism by hydrolyzing triacylglycerols which affects energy storage and utilization.
Pathways
The activity of AADAC is important in the drug metabolism pathway specifically the phase I metabolism where it interacts with different prodrugs and xenobiotics. This enzyme works closely with cytochrome P450 enzymes which are involved in further modifications of chemical substrates during metabolism. AADAC also participates in lipid metabolic pathways influencing lipid and cholesterol absorption and conversion thereby modulating energy balance.
Specifications
Form
Liquid
General info
Function
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
Sequence similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Post-translational modifications
Glycosylation is required for enzyme activity.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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