Recombinant Human AAMDC protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The AAMDC protein also known as Adipogenesis Associated Mth938 Domain Containing Protein is involved in cellular processes related to adipogenesis and cell growth regulation. It has a molecular weight of around 44 kDa. AAMDC shows expression in various tissues including fat tissue where it may play a role in fat cell development and energy metabolism. Scientists have taken an interest in its role due to its involvement in essential cellular mechanisms linked to growth and metabolism.

Biological function summary

The AAMDC protein influences adipogenesis the process by which precursor cells develop into mature adipocytes or fat cells. While AAMDC does not form part of a well-defined protein complex its interactions suggest a role in modulating cellular growth responses. It may act as a modulator affecting the differentiation of cells in energy-intensive processes and potentially tying into larger processes of energy homeostasis.

Pathways

Research places AAMDC within the Wnt signaling and PI3K-Akt pathways both important in cellular growth and metabolism regulation. In these pathways AAMDC can interact with proteins like Akt and GSK-3β known to regulate glucose metabolism and fat storage. AAMDC's role in these pathways suggests it may influence both the proliferation and differentiation of adipocytes which are critical processes in maintaining energy balance and body composition.

Scientists explore AAMDC for its potential connections to obesity and cancer. The protein's role in adipogenesis ties it to obesity where excessive fat cell development and storage occur. Additionally its possible implication in cancer relates to cell growth regulation. Researchers suspect there might be an interplay between AAMDC and oncogenic proteins like mTOR in tumor progression. Understanding these relationships may reveal novel therapeutic targets for both cancer and obesity-related conditions.