Recombinant Human AAMP protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

AAMP also known as angio-associated migratory cell protein is a small protein with a molecular mass of approximately 45 kDa. It is expressed in various tissues including endothelial cells and fibroblasts. The protein interacts with actin-binding proteins and plays a part in cytoskeletal dynamics. It supports cellular processes by influencing cell migration and vascular organization.

Biological function summary

The protein contributes to angiogenesis by promoting the migration and proliferation of endothelial cells necessary for new blood vessel formation. It is not part of a larger complex but still interacts with other proteins involved in the remodeling of the extracellular matrix. AAMP aids in cell adhesion which affects tissue repair and development.

Pathways

AAMP participates in the angiogenic signaling pathway. It interacts with other proteins such as integrins to mediate cellular responses to growth factors like VEGF (vascular endothelial growth factor). This coordination ensures proper vascular development and function. The protein integrates into pathways that control the actin cytoskeleton further contributing to motility and structure of cells.

Associated diseases and disorders

AAMP shows relevance to cancer and cardiovascular disease. Its role in angiogenesis connects it to tumor growth where increased blood supply can promote cancer progression. Additionally AAMP's interaction with VEGF links it to cardiovascular disorders where aberrant vascular growth is a concern. As such AAMP may serve as a potential target in therapeutic strategies addressing these conditions.