Recombinant Human ABCA10 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ABCA10 is an ATP-binding cassette transporter which is part of a large family of proteins involved in the transport of molecules across cellular membranes. The protein has an approximate mass of 186 kDa. It is commonly known by its full name ATP-binding cassette sub-family A member 10. ABCA10 gets expressed largely in the peripheral tissues notably within vascular tissues. Its mechanical role involves ATP-dependent transport of lipids and other substrates across membranes although its specific substrates remain under study.

Biological function summary

ABCA10 contributes to lipid homeostasis and is associated with the regulation of lipid transport and metabolism. It is not known to be part of a large macromolecular complex suggesting an independent function. Given the involvement of other ABC transporters in similar activities ABCA10 likely participates in cellular processes that maintain lipid balance and influence lipid composition within cells.

Pathways

ABCA10 contributes to cellular lipid transport mechanisms which directly link it to lipid metabolic pathways. The protein shares functional similarities with other ABC transporters like ABCA1 which also has significant roles in lipid efflux and cholesterol transport. This connection might indicate overlapping or complementary functions in lipid regulation pathways impacting the maintenance of cellular lipid levels and promoting lipid homeostasis.

Altered ABCA10 function may implicate cardiovascular disorders or metabolic diseases given its role in lipid transport. Abnormalities in related transporters such as ABCA1 have been implicated in conditions like Tangier disease and atherosclerosis. While direct associations to such diseases for ABCA10 are less established dysregulation in similar pathways suggests potential links to disorders affecting lipid metabolism and vascular health.