Recombinant Human ABCA5 protein is a Human Fragment protein, in the 1464 to 1642 aa range, expressed in Escherichia coli, with =90% purity and suitable for SDS-PAGE.
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity).
KIAA1888, ABCA5, Cholesterol transporter ABCA5, ATP-binding cassette sub-family A member 5
Recombinant Human ABCA5 protein is a Human Fragment protein, in the 1464 to 1642 aa range, expressed in Escherichia coli, with =90% purity and suitable for SDS-PAGE.
Constituents: 0.58% Sodium chloride, 0.32% Tris HCl
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity).
Belongs to the ABC transporter superfamily. ABCA family.
N-glycosylated.
ABCA5 also known as ATP-binding cassette sub-family A member 5 functions as a transporter protein. It belongs to the ABC transporter family which utilizes ATP hydrolysis to translocate substrates across cellular membranes. The mass of ABCA5 is approximately 183 kDa. This protein is expressed in various tissues including the brain and testes where it plays a role in cellular lipid transport processes.
The ABCA5 protein impacts lipid metabolism and the maintenance of cellular lipid homeostasis. The protein is not known to be part of any complex but it actively contributes to the movement of cholesterol and other lipid molecules out of cells affecting their availability and distribution. This process supports cellular function and integrity by managing lipid storage and mobilization.
ABCA5 plays a significant role in lipid transport and metabolism pathways and cholesterol efflux. It interacts with proteins such as ABCA1 which is also part of the ABC transporter family and facilitates the removal of cholesterol from cells impacting cholesterol homeostasis. These interactions are vital for the proper functioning of lipid management pathways.
Under-functioning or mutations in ABCA5 can associate with lipid storage disorders impacting cellular and systemic lipid regulations. The protein has connections to conditions such as Niemann-Pick disease where lipid accumulation occurs due to disrupted transport. Protein interactions between ABCA5 and proteins like NPC1 involved in Niemann-Pick disease offer insights into the disease mechanisms.
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