Recombinant Human ABHD10 protein (His tag N-Terminus)
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Recombinant Human ABHD10 protein (His tag N-Terminus) is a Human Full Length protein, in the 53 to 306 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Acyl-protein thioesterase ABHD10, Alpha/beta hydrolase domain-containing protein 10, Abhydrolase domain-containing protein 10, ABHD10
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human ABHD10 protein (His tag N-Terminus) (AB126655)
15% SDS-PAGE showing ab126655 (3µg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The enzyme ABHD10 regulates metabolic functions related to lipid homeostasis. It engages in deacetylation activities that affect the redox state within cells. ABHD10 itself does not form large complexes but can interact with other metabolic enzymes to influence their activity. Its presence supports cellular antioxidant defenses helping maintain cellular environment stability.
Pathways
ABHD10 is integral to the lipid metabolic pathway and the antioxidant defense mechanisms. It functions alongside proteins such as peroxiredoxins in maintaining efficient removal of reactive oxygen species (ROS). The enzyme's interaction with lipid molecules and regulatory proteins form a part of the broader metabolic regulatory network which is essential for lipid degradation and balance.
Specifications
Form
Liquid
Additional notes
ab126655 is purified using conventional chromatography techniques
General info
Function
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed : 31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed : 31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (PubMed : 22294686).
Sequence similarities
Belongs to the AB hydrolase superfamily.
Subcellular localisation
Mitochondrion
Target data
Complementary Products
Product promise
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