JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB181894

Recombinant Human ABHD12B protein (denatured)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human ABHD12B protein (denatured) is a Human Full Length protein, in the 1 to 255 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

C14orf29, ABHD12B, Protein ABHD12B, Abhydrolase domain-containing protein 12B, Alpha/beta hydrolase domain-containing protein 12B

1 Images
SDS-PAGE - Recombinant Human ABHD12B protein (denatured) (AB181894)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ABHD12B protein (denatured) (AB181894)

SDS-PAGE analysis of Recombinant Human ABHD12B protein (ab181894), under reducing conditions. Proteins visualized by coomassie blue stain.

Lane 1 : Molecular Weight Standards

Lane 2 : 3 μg Recombinant Human ABHD12B protein

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q7Z5M8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLGIWHTVPSCRGEDAKGKDCCWYEAALRDGNPIIVYLHGSAEHRAASHRLKLVKVLSDGGFHVLSVDYRGFGDSTGKPTEEGLTTDAICVYEWTKARSGITPVCLWGHSLGTGVATNAAKVLEEKGCPVDAIVLEAPFTNMWVASINYPLLKIYRNIPGFLRTLMDALRKDKIIFPNDENVKFLSSPLLILHGEDDRTVPLEYGKKLYEIARNAYRNKERVKMVIFPPGFQHNLLCKSPTLLITVRDFLSKQWS","proteinLength":"Full Length","predictedMolecularWeight":"31 kDa","actualMolecularWeight":null,"aminoAcidEnd":255,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q7Z5M8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ABHD12B known as alpha/beta hydrolase domain-containing protein 12B functions mechanically as a hydrolytic enzyme. It participates in lipid metabolism by breaking down specific substrates through its hydrolase activity. The target has a molecular mass of approximately 45 kDa. Expression of ABHD12B occurs in various tissues with noted presence in the brain and other organs involved in lipid regulation.
Biological function summary

ABHD12B contributes to the regulation of lipid signaling pathways. This enzyme plays a role in maintaining lipid homeostasis impacting signaling molecules like lysophosphatidylserines. ABHD12B does not function alone; it may interact with other proteins within a larger enzymatic complex. This interaction influences cellular processes by modifying bioactive lipids that serve as signaling messengers.

Pathways

ABHD12B participates in the endocannabinoid signaling pathway and the phosphatidylserine metabolism pathway. These pathways are critical in cellular communication and homeostatic balance. In these pathways ABHD12B collaborates with proteins like phospholipase A2 and cannabinoid receptors. Its actions influence the concentration of lipid-derived signals that modulate receptor activity and cellular responses.

ABHD12B has potential connections to neurodegenerative diseases and metabolic disorders. Dysregulation of its activity might lead to abnormal lipid accumulation or signaling disruption underlying disorders such as neurodegeneration. The target shows functional linkage to proteins implicated in these conditions such as ABHD12 and presenilin suggesting a role in the pathological progression of these disorders. Understanding ABHD12B's involvement in these diseases offers potential therapeutic avenues targeting lipid metabolic pathways.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Sequence similarities

Belongs to the serine esterase family.

style
left-column

Product protocols

style
left-column

Target data

See full target information ABHD12B
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB181905

Recombinant Human ZCCHC12 protein (denatured)

SDS-PAGE - Recombinant Human ZCCHC12 protein (denatured) (AB181905)

  • 0
  • 0
Proteins & Peptides

AB183259

Recombinant Human TSR2 protein

SDS-PAGE - Recombinant Human TSR2 protein (AB183259)

  • 0
  • 0
Proteins & Peptides

AB276624

Recombinant Human TXNDC/TMX protein (Fc Chimera)

SDS-PAGE - Recombinant Human TXNDC/TMX protein (Fc Chimera) (AB276624)

  • 0
  • 0
Proteins & Peptides

AB181934

Recombinant Human ZNF32 protein (denatured)

SDS-PAGE - Recombinant Human ZNF32 protein (denatured) (AB181934)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com