Recombinant Human ABI3 protein (denatured) is a Human Full Length protein, in the 1 to 366 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M A E L Q Q L Q E F E I P T G R E A L R G N H S A L L R V A D Y C E D N Y V Q A T D K R K A L E E T M A F T T Q A L A S V A Y Q V G N L A G H T L R M L D L Q G A A L R Q V E A R V S T L G Q M V N M H M E K V A R R E I G T L A T V Q R L P P G Q K V I A P E N L P P L T P Y C R R P L N F G C L D D I G H G I K D L S T Q L S R T G T L S R K S I K A P A T P A S A T L G R P P R I P E P V H L P V V P D G R L S A A S S A S S L A S A G S A E G V G G A P T P K G Q A A P P A P P L P S S L D P P P P P A A V E V F Q R P P T L E E L S P P P P D E E L P L P L D L P P P P P L D G D E L G L P P P P P G F G P D E P S W V P A S Y L E K V V T L Y P Y T S Q K D N E L S F S E G T V I C V T R R Y S D G W C E G V S S E G T G F F P G N Y V E P S C
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
Alternative names
NESH, ABI3, ABI gene family member 3, New molecule including SH3, Nesh
Recommended products
Recombinant Human ABI3 protein (denatured) is a Human Full Length protein, in the 1 to 366 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9P2A4-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M A E L Q Q L Q E F E I P T G R E A L R G N H S A L L R V A D Y C E D N Y V Q A T D K R K A L E E T M A F T T Q A L A S V A Y Q V G N L A G H T L R M L D L Q G A A L R Q V E A R V S T L G Q M V N M H M E K V A R R E I G T L A T V Q R L P P G Q K V I A P E N L P P L T P Y C R R P L N F G C L D D I G H G I K D L S T Q L S R T G T L S R K S I K A P A T P A S A T L G R P P R I P E P V H L P V V P D G R L S A A S S A S S L A S A G S A E G V G G A P T P K G Q A A P P A P P L P S S L D P P P P P A A V E V F Q R P P T L E E L S P P P P D E E L P L P L D L P P P P P L D G D E L G L P P P P P G F G P D E P S W V P A S Y L E K V V T L Y P Y T S Q K D N E L S F S E G T V I C V T R R Y S D G W C E G V S S E G T G F F P G N Y V E P S C
- Accession
- Q9P2A4
- Protein length
- Full Length
- Predicted molecular weight
- 41.4 kDa
- Amino acids
- 1 to 366
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
- Sequence similarities
Belongs to the ABI family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ABI3 also known as the ATP-binding cassette sub-family I member 3 is a protein involved in lipid transport and metabolism. It weighs approximately 34 kDa. This protein is expressed in various tissues most notably in the brain and immune cells. The presence of ABI3 has been noted in microglia which are the brain’s resident macrophages highlighting its significance in central nervous system functioning.
- Biological function summary
The protein ABI3 plays an essential role in phagocytic activity which helps in clearing cellular debris and toxins supporting immune response and maintenance of tissue homeostasis. ABI3 integrates into a larger macromolecular complex where it interacts with other proteins to influence phagocytosis efficiency. Such interactions empower ABI3 to modulate inflammatory responses thereby contributing to cellular defense mechanisms.
- Pathways
Different cellular processes involve ABI3 especially the PI3K-Akt pathway and the immune response pathways. The PI3K-Akt pathway is critical for cell survival and growth where ABI3 modulates these activities. ABI3 interacts with other proteins in this pathway like AKT1 to impact cellular metabolism and survival decisions. Furthermore its involvement in immune response pathways highlights its role in maintaining cellular health through modulating both inflammation and phagocytosis.
- Associated diseases and disorders
ABI3 has associations with neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. Its role in affected microglial function directly links to inflammatory processes observed in these conditions. Additionally ABI3 interacts with proteins like TREM2 in microglial cells which research connects to Alzheimer’s disease offering insights into potential therapeutic targets.
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1 product image
SDS-PAGE - Recombinant Human ABI3 protein (denatured) (ab134548)
15% SDS-PAGE analysis of 3μg ab134548.
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