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AB134548

Recombinant Human ABI3 protein (denatured) (His tag N-Terminus)

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Recombinant Human ABI3 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 366 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

NESH, ABI3, ABI gene family member 3, New molecule including SH3, Nesh

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SDS-PAGE - Recombinant Human ABI3 protein (denatured) (His tag N-Terminus) (AB134548)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ABI3 protein (denatured) (His tag N-Terminus) (AB134548)

15% SDS-PAGE analysis of 3μg ab134548.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9P2A4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALASVAYQVGNLAGHTLRMLDLQGAALRQVEARVSTLGQMVNMHMEKVARREIGTLATVQRLPPGQKVIAPENLPPLTPYCRRPLNFGCLDDIGHGIKDLSTQLSRTGTLSRKSIKAPATPASATLGRPPRIPEPVHLPVVPDGRLSAASSASSLASAGSAEGVGGAPTPKGQAAPPAPPLPSSLDPPPPPAAVEVFQRPPTLEELSPPPPDEELPLPLDLPPPPPLDGDELGLPPPPPGFGPDEPSWVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGNYVEPSC","proteinLength":"Full Length","predictedMolecularWeight":"41.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":366,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9P2A4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ABI3 also known as the ATP-binding cassette sub-family I member 3 is a protein involved in lipid transport and metabolism. It weighs approximately 34 kDa. This protein is expressed in various tissues most notably in the brain and immune cells. The presence of ABI3 has been noted in microglia which are the brain’s resident macrophages highlighting its significance in central nervous system functioning.
Biological function summary

The protein ABI3 plays an essential role in phagocytic activity which helps in clearing cellular debris and toxins supporting immune response and maintenance of tissue homeostasis. ABI3 integrates into a larger macromolecular complex where it interacts with other proteins to influence phagocytosis efficiency. Such interactions empower ABI3 to modulate inflammatory responses thereby contributing to cellular defense mechanisms.

Pathways

Different cellular processes involve ABI3 especially the PI3K-Akt pathway and the immune response pathways. The PI3K-Akt pathway is critical for cell survival and growth where ABI3 modulates these activities. ABI3 interacts with other proteins in this pathway like AKT1 to impact cellular metabolism and survival decisions. Furthermore its involvement in immune response pathways highlights its role in maintaining cellular health through modulating both inflammation and phagocytosis.

ABI3 has associations with neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. Its role in affected microglial function directly links to inflammatory processes observed in these conditions. Additionally ABI3 interacts with proteins like TREM2 in microglial cells which research connects to Alzheimer’s disease offering insights into potential therapeutic targets.
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Specifications

Form

Liquid

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General info

Function

May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.

Sequence similarities

Belongs to the ABI family.

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Product protocols

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Target data

May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
See full target information ABI3
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