Recombinant human ABL2 protein
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Recombinant human ABL2 protein is a Human Fragment protein, in the 38 to 1167 aa range, expressed in Baculovirus infected Sf9 cells, with >70%, suitable for FuncS.
View Alternative Names
ABLL, ARG, ABL2, Tyrosine-protein kinase ABL2, Abelson murine leukemia viral oncogene homolog 2, Abelson tyrosine-protein kinase 2, Abelson-related gene protein, Tyrosine-protein kinase ARG
- FuncS
Unknown
Functional Studies - Recombinant human ABL2 protein (AB51259)
The specific activity of ABL2 (ab51259) was determined to be 1050 nmol/min/mg as per activity assay protocol
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human ABL2 protein (AB51259)
Sample Purity Data.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human ABL2 protein (AB51259)
SDS PAGE analysis of ab51259
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ABL2 contributes to cellular processes such as actin cytoskeleton remodeling cell migration and adhesion. This protein interacts with different binding partners through its SH2 and SH3 domains implicating it in cellular signal transduction. ABL2 has been observed to occasionally form part of complexes that regulate these processes contributing to dynamic changes in cell morphology and motility.
Pathways
ABL2 plays a significant role in the downstream signaling of receptor tyrosine kinases and integrins linking it to pathways like the PDGF and VEGF signaling pathways. ABL2 interacts with proteins such as CRK and C3G which influence cytoskeletal reorganization and cellular responses to external stimuli. These interactions highlight its role in conveying signals from the cell surface to internal signaling cascades.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity).
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
Post-translational modifications
Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity).. Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.
Subcellular localisation
Cytoskeleton
Target data
Complementary Products
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