Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesOur latest ELISA kit: Human Tau (phospho T217) - Intracellular
Highly sensitive kit offering the most promising biomarkers for Alzheimer’s disease diagnostics. Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Recombinant Human ACE2 protein is a Human Fragment protein, in the 18 to 740 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
Alternative names=Angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, Angiotensin-converting enzyme-related carboxypeptidase, Metalloprotease MPROT15, ACEH, ACE-related carboxypeptidase, UNQ868/PRO1885, ACE2
>95% SDS-PAGE
< 1 EU/µg
HEK 293 cells
His tag C-Terminus
SDS-PAGE, HPLC
No
Q S T I E E Q A K T F L D K F N H E A E D L F Y Q S S L A S W N Y N T N I T E E N V Q N M N N A G D K W S A F L K E Q S T L A Q M Y P L Q E I Q N L T V K L Q L Q A L Q Q N G S S V L S E D K S K R L N T I L N T M S T I Y S T G K V C N P D N P Q E C L L L E P G L N E I M A N S L D Y N E R L W A W E S W R S E V G K Q L R P L Y E E Y V V L K N E M A R A N H Y E D Y G D Y W R G D Y E V N G V D G Y D Y S R G Q L I E D V E H T F E E I K P L Y E H L H A Y V R A K L M N A Y P S Y I S P I G C L P A H L L G D M W G R F W T N L Y S L T V P F G Q K P N I D V T D A M V D Q A W D A Q R I F K E A E K F F V S V G L P N M T Q G F W E N S M L T D P G N V Q K A V C H P T A W D L G K G D F R I L M C T K V T M D D F L T A H H E M G H I Q Y D M A Y A A Q P F L L R N G A N E G F H E A V G E I M S L S A A T P K H L K S I G L L S P D F Q E D N E T E I N F L L K Q A L T I V G T L P F T Y M L E K W R W M V F K G E I P K D Q W M K K W W E M K R E I V G V V E P V P H D E T Y C D P A S L F H V S N D Y S F I R Y Y T R T L Y Q F Q F Q E A L C Q A A K H E G P L H K C D I S N S T E A G Q K L F N M L R L G K S E P W T L A L E N V V G A K N M N V R P L L N Y F E P L F T W L K D Q N K N S F V G W S T D W S P Y A D Q S I K V R I S L K S A L G D K A Y E W N D N E M Y L F R S S V A Y A M R Q Y F L K V K N Q M I L F G E E D V R V A N L K P R I S F N F F V T A P K N V S D I I P R T E V E K A I R M S R S R I N D A F R L N D N S L E F L G I Q P T L G P P N Q P P V S V D H H H H H H
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Recombinant Human ACE2 protein is a Human Fragment protein, in the 18 to 740 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
Alternative names=Angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, Angiotensin-converting enzyme-related carboxypeptidase, Metalloprotease MPROT15, ACEH, ACE-related carboxypeptidase, UNQ868/PRO1885, ACE2
>95% SDS-PAGE
< 1 EU/µg
HEK 293 cells
His tag C-Terminus
SDS-PAGE, HPLC
No
84.6 kDa
18 to 740
Q S T I E E Q A K T F L D K F N H E A E D L F Y Q S S L A S W N Y N T N I T E E N V Q N M N N A G D K W S A F L K E Q S T L A Q M Y P L Q E I Q N L T V K L Q L Q A L Q Q N G S S V L S E D K S K R L N T I L N T M S T I Y S T G K V C N P D N P Q E C L L L E P G L N E I M A N S L D Y N E R L W A W E S W R S E V G K Q L R P L Y E E Y V V L K N E M A R A N H Y E D Y G D Y W R G D Y E V N G V D G Y D Y S R G Q L I E D V E H T F E E I K P L Y E H L H A Y V R A K L M N A Y P S Y I S P I G C L P A H L L G D M W G R F W T N L Y S L T V P F G Q K P N I D V T D A M V D Q A W D A Q R I F K E A E K F F V S V G L P N M T Q G F W E N S M L T D P G N V Q K A V C H P T A W D L G K G D F R I L M C T K V T M D D F L T A H H E M G H I Q Y D M A Y A A Q P F L L R N G A N E G F H E A V G E I M S L S A A T P K H L K S I G L L S P D F Q E D N E T E I N F L L K Q A L T I V G T L P F T Y M L E K W R W M V F K G E I P K D Q W M K K W W E M K R E I V G V V E P V P H D E T Y C D P A S L F H V S N D Y S F I R Y Y T R T L Y Q F Q F Q E A L C Q A A K H E G P L H K C D I S N S T E A G Q K L F N M L R L G K S E P W T L A L E N V V G A K N M N V R P L L N Y F E P L F T W L K D Q N K N S F V G W S T D W S P Y A D Q S I K V R I S L K S A L G D K A Y E W N D N E M Y L F R S S V A Y A M R Q Y F L K V K N Q M I L F G E E D V R V A N L K P R I S F N F F V T A P K N V S D I I P R T E V E K A I R M S R S R I N D A F R L N D N S L E F L G I Q P T L G P P N Q P P V S V D H H H H H H
Fragment
No
Recombinant
Human
pH: 7.4
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.001% Zinc chloride
Liquid
Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042, PubMed:10924499, PubMed:11815627, PubMed:19021774, PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582).
Belongs to the peptidase M2 family.
N-glycosylation on Asn-90 may limit SARS infectivity.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com