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AB159104

Recombinant Human Aciculin protein

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Recombinant Human Aciculin protein is a Human Full Length protein, in the 1 to 506 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

PGMRP, PGM5, Phosphoglucomutase-like protein 5, Aciculin, Phosphoglucomutase-related protein, PGM-RP

1 Images
SDS-PAGE - Recombinant Human Aciculin protein (AB159104)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Aciculin protein (AB159104)

ab159104 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q15124

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Phosphoglucomutase 5.
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Sequence info

[{"sequence":"MVVGSDGRYFSRTAIEIVVQMAAANGIGRLIIGQNGILSTPAVSCIIRKIKAAGGIILTASHCPGGPGGEFGVKFNVANGGPAPDVVSDKIYQISKTIEEYAICPDLRIDLSRLGRQEFDLENKFKPFRVEIVDPVDIYLNLLRTIFDFHAIKGLLTGPSQLKIRIDAMHGVMGPYVRKVLCDELGAPANSAINCVPLEDFGGQHPDPNLTYATTLLEAMKGGEYGFGAAFDADGDRYMILGQNGFFVSPSDSLAIIAANLSCIPYFRQMGVRGFGRSMPTSMALDRVAKSMKVPVYETPAGWRFFSNLMDSGRCNLCGEESFGTGSDHLREKDGLWAVLVWLSIIAARKQSVEEIVRDHWAKFGRHYYCRFDYEGLDPKTTYYIMRDLEALVTDKSFIGQQFAVGSHVYSVAKTDSFEYVDPVDGTVTKKQGLRIIFSDASRLIFRLSSSSGVRATLRLYAESYERDPSGHDQEPQAVLSPLIAIALKISQIHERTGRRGPTVIT","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":506,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q15124","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aciculin also known as gamma-filamin or filamin C is a protein involved in mechanotransduction and cellular structural integrity. It has a molecular mass of approximately 290 kDa. Aciculin is expressed primarily in skeletal and cardiac muscle tissues providing stability and flexibility to the cellular cytoskeleton. It plays an essential role in connecting the actin cytoskeleton to various cell membrane components facilitating cellular shape and movement.
Biological function summary

Aciculin is essential for cytoskeletal organization and cell adhesion processes. It acts within a complex network of proteins that includes integrins and sarcoglycans assisting in mechanical signal transduction across muscle cells. This interaction supports muscle cell structure and integrity allowing proper muscle function during contraction and relaxation phases. It also helps in repairing cell membrane disruptions caused by mechanical stress.

Pathways

The protein contributes significantly to actin filament organization and integrin-mediated signaling pathways. These pathways are important for maintaining muscle cell strength and stability. Aciculin interacts with proteins like vinculin and talin enhancing its role in actin cytoskeleton rearrangement processes and integrin signal transduction. As a result it helps ensure cell adhesion and motility by linking cytoskeletal elements to extracellular matrix components.

Mutations or defects in Aciculin are associated with conditions such as myofibrillar myopathy and cardiomyopathy. These disorders are characterized by muscle weakness and deterioration due to impaired cytoskeletal stability. In these cases Aciculin’s interaction with dystrophin becomes critical as dystrophin abnormalities can compound issues with muscle integrity and function. Understanding how Aciculin functions in these contexts is important for developing therapeutic approaches to muscular disorders.
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Specifications

Form

Liquid

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General info

Function

Component of adherens-type cell-cell and cell-matrix junctions (PubMed : 8175905). Has no phosphoglucomutase activity in vitro (PubMed : 8175905).

Sequence similarities

Belongs to the phosphohexose mutase family.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Component of adherens-type cell-cell and cell-matrix junctions (PubMed : 8175905). Has no phosphoglucomutase activity in vitro (PubMed : 8175905).
See full target information PGM5
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Product promise

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