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AB159987

Recombinant Human ACOX3 protein (GST tag N-Terminus)

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Recombinant Human ACOX3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 624 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

BRCOX, PRCOX, ACOX3, Peroxisomal acyl-coenzyme A oxidase 3, Branched-chain acyl-CoA oxidase, Pristanoyl-CoA oxidase, BRCACox

1 Images
SDS-PAGE - Recombinant Human ACOX3 protein (GST tag N-Terminus) (AB159987)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ACOX3 protein (GST tag N-Terminus) (AB159987)

ab159987 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

O15254

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSLSRHAALLYRAERRCSCPGRRDRSS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":624,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O15254","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ACOX3 also known as acyl-CoA oxidase 3 or PRACOX3 is an enzyme that functions in the peroxisomal beta-oxidation of branched-chain fatty acids. It specifically catalyzes the first oxidation step introducing a double bond between alpha and beta carbon of Acyl-CoA esters. ACOX3 has a molecular mass of approximately 75 kDa. Expression of ACOX3 primarily occurs in liver and kidney tissues where it plays a significant role in lipid metabolism.
Biological function summary

ACOX3 contributes to the breakdown of pristanic acid a branched-chain fatty acid derived from phytanic acid. It functions as part of a peroxisomal enzyme system that efficiently oxidizes fatty acids that contain branches on their carbon chains which mitochondria can’t oxidize. ACOX3 works alongside other enzymes like ACOX1 and ACOX2 which oxidize different substrates ensuring a specialized fatty acid metabolism in the cell.

Pathways

ACOX3 plays a critical role in the peroxisomal fatty acid beta-oxidation pathway also contributing to the catabolism of very-long-chain fatty acids. This pathway complements the mitochondrial beta-oxidation providing a synergistic approach for complete fatty acid degradation. ACOX3 works closely related to proteins like peroxisomal bifunctional enzyme and thiolase completing the sequential steps necessary for beta-oxidation and energy production from fatty acids.

Mutations or dysfunctions in ACOX3 can lead to disruptions in fatty acid metabolism particularly affecting the metabolism of branched-chain fatty acids and potentially contributing to conditions such as Refsum disease or Zellweger syndrome. These disorders often exhibit accumulation of toxic metabolites causing harmful effects in tissues. They link ACOX3 dysfunction to broader peroxisomal biogenesis issues that involve other enzymes such as the PEX proteins which are vital for normal peroxisomal function and maintenance.
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Specifications

Form

Liquid

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General info

Function

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

Subcellular localisation

Peroxisome

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Product protocols

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Target data

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
See full target information ACOX3
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