Recombinant Human ACPL2 protein (His tag) is a Human Full Length protein, in the 1 to 480 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M L F R N R F L L L L A L A A L L A F V S L S L Q F F H L I P V S T P K N G M S S K S R K R I M P D P V T E P P V T D P V Y E A L L Y C N I P S V A E R S M E G H A P H H F K L V S V H V F I R H G D R Y P L Y V I P K T K R P E I D C T L V A N R K P Y H P K L E A F I S H M S K G S G A S F E S P L N S L P L Y P N H P L C E M G E L T Q T G V V Q H L Q N G Q L L R D I Y L K K H K L L P N D W S A D Q L Y L E T T G K S R T L Q S G L A L L Y G F L P D F D W K K I Y F R H Q P S A L F C S G S C Y C P V R N Q Y L E K E Q R R Q Y L L R L K N S Q L E K T Y G E M A K I V D V P T K Q L R A A N P I D S M L C H F C H N V S F P C T R N G C V D M E H F K V I K T H Q I E D E R E R R E K K L Y F G Y S L L G A H P I L N Q T I G R M Q R A T E G R K E E L F A L Y S A H D V T L S P V L S A L G L S E A R F P R F A A R L I F E L W Q D R E K P S E H S V R I L Y N G V D V T F H T S F C Q D H H K R S P K P M C P L E N L V R F V K R D M F V A L G G S G T N Y Y D A C H R E G F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.
Alternative names
ACPL2, HEL124, XYLP, UNQ370/PRO706, PXYLP1, 2-phosphoxylose phosphatase 1, Acid phosphatase-like protein 2, Xylosyl phosphatase, epididymis luminal protein 124
Recommended products
Recombinant Human ACPL2 protein (His tag) is a Human Full Length protein, in the 1 to 480 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q8TE99-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M L F R N R F L L L L A L A A L L A F V S L S L Q F F H L I P V S T P K N G M S S K S R K R I M P D P V T E P P V T D P V Y E A L L Y C N I P S V A E R S M E G H A P H H F K L V S V H V F I R H G D R Y P L Y V I P K T K R P E I D C T L V A N R K P Y H P K L E A F I S H M S K G S G A S F E S P L N S L P L Y P N H P L C E M G E L T Q T G V V Q H L Q N G Q L L R D I Y L K K H K L L P N D W S A D Q L Y L E T T G K S R T L Q S G L A L L Y G F L P D F D W K K I Y F R H Q P S A L F C S G S C Y C P V R N Q Y L E K E Q R R Q Y L L R L K N S Q L E K T Y G E M A K I V D V P T K Q L R A A N P I D S M L C H F C H N V S F P C T R N G C V D M E H F K V I K T H Q I E D E R E R R E K K L Y F G Y S L L G A H P I L N Q T I G R M Q R A T E G R K E E L F A L Y S A H D V T L S P V L S A L G L S E A R F P R F A A R L I F E L W Q D R E K P S E H S V R I L Y N G V D V T F H T S F C Q D H H K R S P K P M C P L E N L V R F V K R D M F V A L G G S G T N Y Y D A C H R E G F
- Accession
- Q8TE99
- Protein length
- Full Length
- Predicted molecular weight
- 54 kDa
- Amino acids
- 1 to 480
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.
- Sequence similarities
Belongs to the histidine acid phosphatase family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ACPL2 also known as acid phosphatase-like 2 is an enzyme that hydrolyzes phosphate groups from various substrates at acidic pH. This protein has a molecular mass of approximately 52 kDa and is expressed in multiple tissues including liver kidney and heart. As a phosphatase ACPL2 plays a role in dephosphorylation which is a critical process for regulating protein function and signal transduction.
- Biological function summary
ACPL2 participates in cellular processes through its enzymatic dephosphorylation activity impacting how cells respond to internal and external signals. This protein does not function as part of a larger complex indicating its independent role in its biological functions. By removing phosphate groups from specific substrates ACPL2 can alter the activity interactions and stability of other proteins involved in several cellular mechanisms.
- Pathways
Research indicates that ACPL2 is involved in the regulation of the metabolic and signaling pathways such as glucose metabolism and PI3K-Akt signaling. These pathways integrate signals from various stimuli to regulate cellular growth survival and metabolism. ACPL2 has related interactions with essential proteins like AKT which is known for its role in the PI3K-Akt signaling pathway that governs cell survival and growth.
- Associated diseases and disorders
ACPL2 has associations with metabolic and cardiovascular disorders. Abnormalities in its activity can link to metabolic syndromes and contribute to the complexity of cardiovascular diseases. ACPL2 interacts with proteins like PTP1B which is a known regulator in insulin signaling and metabolic pathways highlighting its potential role in metabolic disorders. Understanding these interactions could provide insight into therapeutic targets for related diseases.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human ACPL2 protein (His tag) (ab276376)
SDS-PAGE analysis of ab276376
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com