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AB276376

Recombinant Human ACPL2 protein (His tag)

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Recombinant Human ACPL2 protein (His tag) is a Human Full Length protein, in the 1 to 480 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

ACPL2, HEL124, XYLP, UNQ370/PRO706, PXYLP1, 2-phosphoxylose phosphatase 1, Acid phosphatase-like protein 2, Xylosyl phosphatase, epididymis luminal protein 124

1 Images
SDS-PAGE - Recombinant Human ACPL2 protein (His tag) (AB276376)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ACPL2 protein (His tag) (AB276376)

SDS-PAGE analysis of ab276376

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8TE99

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLFRNRFLLLLALAALLAFVSLSLQFFHLIPVSTPKNGMSSKSRKRIMPDPVTEPPVTDPVYEALLYCNIPSVAERSMEGHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYHPKLEAFISHMSKGSGASFESPLNSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLKKHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFDWKKIYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANPIDSMLCHFCHNVSFPCTRNGCVDMEHFKVIKTHQIEDERERREKKLYFGYSLLGAHPILNQTIGRMQRATEGRKEELFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDREKPSEHSVRILYNGVDVTFHTSFCQDHHKRSPKPMCPLENLVRFVKRDMFVALGGSGTNYYDACHREGF","proteinLength":"Full Length","predictedMolecularWeight":"54 kDa","actualMolecularWeight":null,"aminoAcidEnd":480,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8TE99","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ACPL2 also known as acid phosphatase-like 2 is an enzyme that hydrolyzes phosphate groups from various substrates at acidic pH. This protein has a molecular mass of approximately 52 kDa and is expressed in multiple tissues including liver kidney and heart. As a phosphatase ACPL2 plays a role in dephosphorylation which is a critical process for regulating protein function and signal transduction.
Biological function summary

ACPL2 participates in cellular processes through its enzymatic dephosphorylation activity impacting how cells respond to internal and external signals. This protein does not function as part of a larger complex indicating its independent role in its biological functions. By removing phosphate groups from specific substrates ACPL2 can alter the activity interactions and stability of other proteins involved in several cellular mechanisms.

Pathways

Research indicates that ACPL2 is involved in the regulation of the metabolic and signaling pathways such as glucose metabolism and PI3K-Akt signaling. These pathways integrate signals from various stimuli to regulate cellular growth survival and metabolism. ACPL2 has related interactions with essential proteins like AKT which is known for its role in the PI3K-Akt signaling pathway that governs cell survival and growth.

ACPL2 has associations with metabolic and cardiovascular disorders. Abnormalities in its activity can link to metabolic syndromes and contribute to the complexity of cardiovascular diseases. ACPL2 interacts with proteins like PTP1B which is a known regulator in insulin signaling and metabolic pathways highlighting its potential role in metabolic disorders. Understanding these interactions could provide insight into therapeutic targets for related diseases.
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Specifications

Form

Lyophilized

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General info

Function

Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.

Sequence similarities

Belongs to the histidine acid phosphatase family.

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Product protocols

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Target data

Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.
See full target information PXYLP1
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Product promise

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