Recombinant Human Activin A (Active) protein is a Human Fragment protein, in the 311 to 426 aa range, expressed in HEK 293, with >95% purity and < 1 EU/µg endotoxin level.
G L E C D G K V N I C C K K Q F F V S F K D I G W N D W I I A P S G Y H A N Y C E G E C P S H I A G T S G S S L S F H S T V I N H Y R M R G H S P F A N L K S C C V P T K L R P M S M L Y Y D D G Q N I I K K D I Q N M I V E E C G C S
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
Recombinant Human Activin A (Active) protein is a Human Fragment protein, in the 311 to 426 aa range, expressed in HEK 293, with >95% purity and < 1 EU/µg endotoxin level.
Constituents: 91.99% PBS, 8% Trehalose
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Belongs to the TGF-beta family.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Activin A also known by its gene name INHBA is a protein involved in various mechanical processes in the human body. This protein forms part of the transforming growth factor-beta (TGF-β) superfamily and has a molecular weight of approximately 25 kDa for its dimeric forms. Activin A is expressed in many tissues including the pituitary gland reproductive organs and placenta. Researchers often use techniques like the Activin A ELISA test kit to measure its concentration in biological samples.
Activin A plays a significant role in regulating cell differentiation proliferation and apoptosis. As part of a complex Activin A interacts with specific receptors on cell surfaces initiating intracellular signaling cascades that influence these vital processes. It acts as a growth factor in the reproductive system influencing follicle-stimulating hormone (FSH) secretion and is important in embryonic development and wound healing.
Activin A participates in pathways such as the TGF-β signaling pathway and the SMAD protein signaling pathway. Within these pathways it interacts with receptor proteins like type I and type II Activin receptors and downstream SMAD proteins. These interactions enable Activin A to regulate gene expression relevant to various cellular functions.
Altered Activin A levels have associations with conditions like cancer and fibrotic diseases. Its overexpression links to some cancer types including colorectal and prostate cancer where it influences tumor growth and metastasis. Moreover its interaction with proteins like myostatin may contribute to muscle wasting disorders. The dysregulation of these pathways highlights the significance of Activin A in pathophysiology.
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