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AB159622

Recombinant Human ADA2a protein

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Recombinant Human ADA2a protein is a Human Full Length protein, in the 1 to 305 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

TADA2L, KL04P, TADA2A, Transcriptional adapter 2-alpha, Transcriptional adapter 2-like, ADA2-like protein

1 Images
SDS-PAGE - Recombinant Human ADA2a protein (AB159622)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human ADA2a protein (AB159622)

ab159622 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

O75478

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDRLGSFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHRSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKYFINNPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHACRWFLSLEQYLCVYIYINRRDNGVFYVKFYK","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":305,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O75478","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADA2a also known as adenosine deaminase 2 possesses a molecular mass of approximately 55 kDa. It is an enzyme that catalyzes the hydrolytic deamination of adenosine converting it into inosine. ADA2a primarily localizes in extracellular regions and is secreted by immune cells such as monocytes and macrophages. The enzyme has notable expression in tissues like the spleen small intestine and liver.
Biological function summary

The hydrolytic activity of ADA2a contributes to the modulation of immune responses. The enzyme regulates extracellular levels of adenosine a molecule with immunosuppressive properties thereby influencing inflammation and immune activation. Furthermore ADA2a is associated with the monocyte and macrophage activation process and interacts with other proteins as part of immune system complexes. This interaction allows ADA2a to play a role in regulating immune cell function and communication.

Pathways

ADA2a operates within the purine metabolism pathway where it functions to maintain nucleoside balance. It also contributes to the regulation of immune signaling pathways. The enzyme interacts with other metabolic enzymes like adenosine kinase which further modulate adenosine levels and influence immune cell proliferation and differentiation. These interactions place ADA2a as an important player within these pathways exerting influence on the immune response and cellular metabolism.

ADA2a has been linked to conditions such as systemic inflammation and immunodeficiency disorders. The enzyme is involved in disorders like deficiency of adenosine deaminase 2 (DADA2) which results in vascular and immune dysfunction. ADA2a interacts with proteins like tumor necrosis factor (TNF) in these pathological contexts influencing the course of disease through its regulatory effects on inflammation and immune responses. Understanding its role opens potential avenues for therapeutic intervention in related conditions.
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Specifications

Form

Liquid

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General info

Function

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed : 22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed : 22644376).

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed : 22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed : 22644376).
See full target information TADA2A
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