Recombinant Human ADAL protein (denatured)
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Recombinant Human ADAL protein (denatured) is a Human Full Length protein, in the 1 to 267 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.
View Alternative Names
ADAL, ADAL1, N6-Methyl-AMP deaminase, Adenosine deaminase-like protein, N6-mAMP deaminase, N6-methyl-AMP aminohydrolase, HsMAPDA
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human ADAL protein (denatured) (AB180314)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ADAL participates in RNA processing and turnover by acting on adenosine molecules. This enzyme doesn't form part of a larger complex but operates in conjunction with other nucleases and enzymes involved in RNA metabolism. By modifying adenosine ADAL influences the stability and availability of RNA substrates impacting gene expression and downstream cellular events.
Pathways
ADAL functions in purine metabolism and RNA turnover pathways. It works closely with other deaminases such as ADA (Adenosine Deaminase) to maintain nucleotide balance. The enzyme contributes to the proper functioning of these pathways thereby ensuring efficient cellular replication and repair processes. ADAL's activity ensures that cells effectively manage RNA stability impacting processes like protein synthesis and cellular response to stress.
Specifications
Form
Liquid
General info
Function
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed : 21755941, PubMed : 29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed : 21755941, PubMed : 29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed : 21755941).
Sequence similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Target data
Complementary Products
Product promise
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