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AB117063

Recombinant Human ADAM2 protein

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Recombinant Human ADAM2 protein is a Human Full Length protein, in the 1 to 716 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

FTNB, ADAM2, Disintegrin and metalloproteinase domain-containing protein 2, ADAM 2, Cancer/testis antigen 15, Fertilin subunit beta, PH-30, PH30-beta, CT15, PH30

1 Images
SDS-PAGE - Recombinant Human ADAM2 protein (AB117063)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ADAM2 protein (AB117063)

12.5% SDS-PAGE showing ab117063 at approximately 104.76 kDa.
Stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

Tag free

Applications

WB, ELISA, SDS-PAGE

applications

Biologically active

No

Accession

Q99965

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Recombinant protein.</p>" } } }
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Sequence info

[{"sequence":"MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG","proteinLength":"Full Length","predictedMolecularWeight":"104.76 kDa","actualMolecularWeight":null,"aminoAcidEnd":716,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q99965","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAM2 also known as fertilin beta is a member of the ADAM (a disintegrin and metalloprotease) family. It is a protein with a mass of approximately 100 kDa. ADAM2 contains a disintegrin and metalloproteinase domain which are responsible for its adhesive and protease activities. Expression of ADAM2 occurs mainly in the testis especially in mature spermatozoa where it plays essential roles in reproduction processes.
Biological function summary

The ADAM2 protein functions in sperm-egg interactions facilitating sperm binding to the egg's surface during fertilization. It is part of a multi-protein complex that also includes ADAM1 which enhances the binding efficiency to the egg zona pellucida. ADAM2's disintegrin domain is thought to interact with integrins on the egg membrane while the metalloproteinase domain might process surrounding proteins to prepare for fertilization.

Pathways

ADAM2 actively participates in reproduction-related signaling pathways particularly the integrin-mediated cell adhesion pathway. It collaborates with other ADAM family proteins and integrins to ensure successful fertilization. Another important pathway is the gamete fusion pathway where ADAM2 assists in the fusion process alongside other proteins such as ADAM3 ensuring gamete membrane fusion and subsequent fertilization.

Abnormalities in ADAM2 expression or function can lead to male infertility making this protein a biomarker of reproductive health concerns. It has a known association with other ADAM proteins such as ADAM3 which also plays a role in sperm maturation and fertility. Researchers are interested in how alterations in ADAM2 and these related proteins contribute to infertility offering potential insights for therapeutic interventions.
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Specifications

Form

Liquid

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General info

Function

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

Post-translational modifications

The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.

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Product protocols

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Target data

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
See full target information ADAM2
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