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AB191930

Recombinant Human ADAMDEC1 protein

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Recombinant Human ADAMDEC1 protein is a Human Full Length protein, in the 206 to 470 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

ADAM DEC1, A disintegrin and metalloproteinase domain-like protein decysin-1, ADAM-like protein decysin-1, ADAMDEC1

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE, HPLC

applications

Biologically active

No

Accession

O15204

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 0.87% Sodium chloride, 0.32% Tris HCl, 0.01% Zinc chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"KSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTEVDHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"50.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":470,"aminoAcidStart":206,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O15204","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage duration
A few weeks
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle|Reconstitute for long term storage
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target ADAMDEC1 also known by its alternate name a disintegrin and metalloproteinase domain-like decysin-1 is a member of the ADAM protein family. This protein has a molecular mass of approximately 42 kDa. ADAMDEC1 is expressed in tissues such as the gastrointestinal tract liver and immune cells including macrophages and dendritic cells. It consists of a metalloproteinase domain which suggests a mechanical role in protein processing or breakdown outside the cell.
Biological function summary

ADAMDEC1 acts in the degradation of extracellular matrix components and cytokine processing. It does not form part of a complex but rather functions independently to modulate cellular and tissue remodeling. This activity positions ADAMDEC1 as a relevant factor in processes like tissue repair and immune response modulation.

Pathways

ADAMDEC1 participates in pathways related to inflammation and tissue homeostasis. It is involved in the regulation of the inflammatory response pathway and the immune regulation pathway. Through these pathways it interacts with proteins like matrix metalloproteinases and other ADAM family members which coordinate tissue remodeling and immune responses.

ADAMDEC1 is associated with inflammatory bowel disease and liver fibrosis. Inflammatory bowel disease involves a chronic inflammation of the gastrointestinal tract affecting proteins that regulate the immune and inflammatory responses such as cytokines. In liver fibrosis the interaction of ADAMDEC1 with proteins related to excessive scarring including matrix metalloproteinases highlights its role in disease progression and tissue repair dysregulation.
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Specifications

Form

Liquid

Additional notes

Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

May play an important role in the control of the immune response and during pregnancy.

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Product protocols

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Target data

May play an important role in the control of the immune response and during pregnancy.
See full target information ADAM DEC1
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