Recombinant Human ADAMTS18 protein is a Human Fragment protein, in the 712 to 970 aa range, expressed in Escherichia coli, with >70% purity and suitable for SDS-PAGE.
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ADAMTS21, ADAMTS18, A disintegrin and metalloproteinase with thrombospondin motifs 18, ADAM-TS 18, ADAM-TS18, ADAMTS-18
Recombinant Human ADAMTS18 protein is a Human Fragment protein, in the 712 to 970 aa range, expressed in Escherichia coli, with >70% purity and suitable for SDS-PAGE.
Constituents: 0.58% Sodium chloride, 0.32% Tris HCl
Purified via His tag
The precursor is cleaved by a furin endopeptidase.
ADAMTS18 also known as A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 is a protein with a mass of approximately 130 kDa. This protein performs mechanical functions by serving as a peptidase. It processes extracellular matrix components which is important for tissue remodeling and integrity. ADAMTS18 expresses prominently in the placenta lung and heart indicating its role in diverse tissue environments.
The involvement of ADAMTS18 in ECM binding and remodeling illustrates its role in cellular processes like cell adhesion and migration. ADAMTS18 is not widely known to be part of a complex but interacts with various components of the extracellular matrix. Its activity influences the structural modulation necessary for development and healing processes in tissues.
ADAMTS18 plays a role in the extracellular matrix regulation pathway and is important in maintaining ECM structure. It interfaces with other proteins such as collagen and fibronectin during these processes. These interactions ensure ECM stability and proper signaling which are integral to cellular communication and tissue organization.
ADAMTS18 relates significantly to cancer and retinal disorders. In certain cancers dysregulation of ADAMTS18 expression correlates with tumor progression and metastasis due to disrupted ECM dynamics. In retinal disorders abnormal function or expression may lead to structural weakness of retinal tissues. Connections with proteins involved in ECM remodeling like versican highlight its connection to these diseases suggesting potential therapeutic intervention points.
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