Recombinant Human ADAMTS2/NPI protein (GST tag N-Terminus)
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Recombinant Human ADAMTS2/NPI protein (GST tag N-Terminus) is a Human Fragment protein, in the 1112 to 1210 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
PCINP, PCPNI, ADAMTS2, A disintegrin and metalloproteinase with thrombospondin motifs 2, ADAM-TS 2, ADAM-TS2, ADAMTS-2, Procollagen I N-proteinase, Procollagen I/II amino propeptide-processing enzyme, Procollagen N-endopeptidase, PC I-NP, pNPI
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human ADAMTS2/NPI protein (GST tag N-Terminus) (AB160522)
ab160522 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Primary Antibodies
AB314857
Anti-ADAMTS4 antibody [EPR24094-30] - BSA and Azide free
RabMAb|Recombinant
![Western blot - Anti-ADAMTS4 antibody [EPR24094-30] - BSA and Azide free (AB314857)](https://content.abcam.com/products/images/adamts4-antibody-epr24094-30-bsa-and-azide-free-ab314857--western-blot-img422407.jpg)
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Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The protein functions as a procollagen N-proteinase responsible for collagen synthesis and maturation. The protein is not part of a complex but it interacts directly with collagen molecules to perform its enzymatic activity. By removing propeptides from procollagens ADAMTS2 enables the formation of mature collagen fibrils contributing to the structural integrity of connective tissue.
Pathways
ADAMTS2 is actively involved in the collagen biosynthesis and modifying enzymes pathway. It works closely with the transforming growth factor beta (TGF-β) signaling pathway which regulates fibrosis and wound healing processes. Proteins related through these pathways include tissue inhibitors of metalloproteinases (TIMPs) and other members of the ADAMTS family which together coordinate collagen turnover and tissue remodeling.
Specifications
Form
Liquid
General info
Function
Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (PubMed : 31152061).
Post-translational modifications
The precursor is cleaved by a furin endopeptidase.. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
Target data
Product promise
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