Recombinant Human ADAMTS7 protein (GST tag N-Terminus)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human ADAMTS7 protein (GST tag N-Terminus) is a Human Fragment protein, in the 1589 to 1686 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
A disintegrin and metalloproteinase with thrombospondin motifs 7, ADAM-TS 7, ADAM-TS7, ADAMTS-7, ADAMTS7
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human ADAMTS7 protein (GST tag N-Terminus) (AB153160)
ab153160 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Primary Antibodies
AB195045
BOND RX™ Validated|RabMAb|Recombinant|20ul selling size
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAX6 antibody [EPR15858] (AB195045)](https://content.abcam.com/products/images/pax6-antibody-epr15858-ab195045--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img22939.jpg)
- 5
- 9
Primary Antibodies
AB281192
Anti-ADAMTS1 antibody [EPR23324-54] - BSA and Azide free (Capture)
RabMAb|Recombinant
![Sandwich ELISA - Anti-ADAMTS1 antibody [EPR23324-54] - BSA and Azide free (Capture) (AB281192)](https://content.abcam.com/products/images/adamts1-antibody-epr23324-54-bsa-and-azide-free-capture-ab281192--sandwich-elisa-img438617.jpg)
- 0
- 0
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ADAMTS7 functions as an important regulatory enzyme involved in the processing of cartilage oligomeric matrix protein (COMP). This process impacts the integrity and function of cartilage suggesting its vital role in maintaining cartilage homeostasis. Though it does not form part of a larger complex ADAMTS7 interacts closely with extracellular matrix components modulating cellular processes connected to tissue organization and structural integrity.
Pathways
ADAMTS7 is integral to the extracellular matrix organization pathway impacting its degradation and synthesis. It is also associated with the focal adhesion pathway which is critical for cell adhesion migration and signal transduction. In these pathways ADAMTS7 acts alongside proteins such as integrins and other matrix metalloproteinases coordinating cellular responses to mechanical and chemical stimuli through direct protein interactions.
Specifications
Form
Liquid
General info
Function
Metalloprotease (PubMed : 16585064, PubMed : 39672391). Was previously shown to degrade COMP (PubMed : 16585064). However, a later study found no activity against COMP (PubMed : 39672391).
Post-translational modifications
N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion.. O-glycosylated proteoglycan; contains chondroitin sulfate.. May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed (PubMed:15192113).
Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com