Recombinant Human ADAMTSL3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTSL3 also known as ADAMTS-like 3 is a secreted glycoprotein that shares structural similarities with ADAMTS family members but lacks protease activity. It weighs approximately 190 kDa and is composed of several domains including thrombospondin type 1 repeats and C-terminal PLAC (Protease and Lacunin) domains. ADAMTSL3 shows expression in multiple tissues including the lungs and the central nervous system indicating its potential significance in diverse physiological processes.

Biological function summary

The ADAMTSL3 protein regulates extracellular matrix organization by interacting with fibrillins and other extracellular matrix components. It may form complexes with other extracellular proteins influencing tissue architecture and stability. The protein also participates in modulating signaling pathways that control cell migration and proliferation which affects tissue repair and development.

Pathways

Research indicates that ADAMTSL3 is involved in TGF-beta signaling and fibrillin microfibril assembly important for maintaining cellular integrity and mechanotransduction. It interacts with proteins such as fibrillin-1 and latent TGF-beta binding proteins which play key roles in the regulation of extracellular matrix dynamics. These interactions highlight ADAMTSL3's contribution to maintaining tissue homeostasis and supporting structural integrity.

Emerging studies link alterations in ADAMTSL3 to psychiatric conditions like schizophrenia potentially due to its influence on neural extracellular matrix components. Additionally there is evidence associating ADAMTSL3 with connective tissue disorders potentially through interactions with fibrillin proteins and their effect on elastic fiber assembly. Identifying these associations aids in understanding the mechanistic pathways that involve ADAMTSL3 and their impacts on health.