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AB101153

Recombinant Human ADAT2 protein

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Recombinant Human ADAT2 protein is a Human Full Length protein, in the 1 to 191 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

DEADC1, ADAT2, tRNA-specific adenosine deaminase 2, Deaminase domain-containing protein 1, tRNA-specific adenosine-34 deaminase subunit ADAT2

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SDS-PAGE - Recombinant Human ADAT2 protein (AB101153)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human ADAT2 protein (AB101153)

ab101153 used in 15% SDS-PAGE (3 μg)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q7Z6V5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMEAKAAPKPAASGACSVSAEETEKWMEEAMHMAKEALENTEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCRQSGKSPSEVFEHTVLYVTVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRAEEAVEMLKTFYKQENPNAPKSKVRKKECQKS","proteinLength":"Full Length","predictedMolecularWeight":"23.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":191,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q7Z6V5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAT2 also known as ADAT2 deaminase plays an important role in RNA editing by converting adenosines to inosines in tRNA molecules. This deaminase has a mass of roughly 50 kDa and is widely expressed in various tissues. Its presence is important for maintaining RNA stability and accurate coding which together plays pivotal part in protein synthesis.
Biological function summary

ADAT2 works as part of the ADAT complex that includes ADAT3. This complex specifically targets anticodon regions of tRNAs. The conversion of adenosine to inosine by ADAT2 changes the reading of certain codons allowing for proper interpretation of genetic code elements important for cell function and viability. ADAT2’s activity impacts the modification process essential for accurate protein translation.

Pathways

Four important mechanisms involve ADAT2 in RNA metabolic processes. It plays an integral role in the post-transcriptional modification of RNA particularly within the tRNA maturation pathway. This pathway collaborates with proteins such as ADAT3 and their interaction governs fidelity in transcribing genetic information into proteins. The editing by ADAT2 ensures that tRNA molecules can correctly interpret codons during translation.

Four recognized conditions involve faulty ADAT2 activity: one is neurodevelopmental disorders where genetic mutations affecting its function impact brain development. Another is some types of cancer where RNA editing disruptions play part in tumorigenic processes. These diseases can involve interactions with other proteins like ADAT3 that need for proper RNA editing balance. Understanding these interactions may help in developing therapeutic strategies targeting RNA editing mechanisms.
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Specifications

Form

Liquid

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General info

Function

Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.

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Product protocols

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Target data

Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
See full target information ADAT2
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Complementary Products

Primary Antibodies

AB122280

Anti-ADAT2 antibody

Immunocytochemistry - Anti-ADAT2 antibody (AB122280)

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