Recombinant Human ADCK2 protein (His-DHFR)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADCK2 also known as AarF Domain Containing Kinase 2 is a protein kinase with an approximate mass of 74 kDa. It displays expression mostly in mitochondrial compartments where it exhibits its mechanical role of transferring phosphates to substrate proteins. This kinase belongs to the ABC1 (Activity of bc1 complex) family of atypical kinases which are characterized by specific serine/threonine phosphorylation activities in various organisms.

Biological function summary

ADCK2 is involved in cellular energy production processes. It maintains a role in the mitochondrial function influencing synthesis and maintenance of the respiratory chain complexes. Although ADCK2 is not a part of the protein complexes directly it acts as a modifier that affects the efficiency of these complexes in energy metabolism. Researchers often focus on its impact within the mitochondrial dynamics realm which is important for cellular health and activity.

Pathways

ADCK2 holds a role in both coenzyme Q biosynthesis and oxidative phosphorylation pathways. Coenzyme Q biosynthesis pathway connects ADCK2 function with several Q biosynthesis proteins such as COQ6. In oxidative phosphorylation ADCK2 contributes indirectly by affecting the electron transport chain's efficiency where it indirectly interacts with proteins such as cytochrome c oxidase components playing roles in ATP production.

Altered ADCK2 expression has relations with mitochondrial myopathies and certain metabolic syndromes. These conditions often involve dysfunctions within the energy production process linking ADCK2 with proteins like COQ10 which are important in the respiratory chain. As such ADCK2 represents a potential target in understanding and addressing these metabolic imbalances and related clinical presentations.