Recombinant Human ADCK5 protein is a Human Fragment protein, in the 68 to 580 aa range, expressed in Baculovirus infected Sf9, with >75% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >75% SDS-PAGE
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M A E A R E K R R M R L V V D G M G R F G R S L K V G L Q I S L D Y W W C T N V V L R G V E E N S P G Y L E V M S A C H Q R A A D A L V A G A I S N G G L Y V K L G Q G L C S F N H L L P P E Y T R T L R V L E D R A L K R G F Q E V D E L F L E D F Q A L P H E L F Q E F D Y Q P I A A A S L A Q V H R A K L H D G T S V A V K V Q Y I D L R D R F D G D I H T L E L L L R L V E V M H P S F G F S W V L Q D L K G T L A Q E L D F E N E G R N A E R C A R E L A H F P Y V V V P R V H W D K S S K R V L T A D F C A G C K V N D V E A I R S Q G L A V H D I A E K L I K A F A E Q I F Y T G F I H S D P H P G N V L V R K G P D G K A E L V L L D H G L Y Q F L E E K D R A A L C Q L W R A I I L R D D A A M R A H A A A L G V Q D Y L L F A E M L M Q R P V R L G Q L W G S H L L S R E E A A Y M V D M A R E R F E A V M A V L R E L P R P M L L V L R N I N T V R A I N V A L G A P V D R Y F L M A K R A V R G W S R L A G A T Y R G V Y G T S L L R H A K V V W E M L K F E V A L R L E T L A M R L T A L L A R A L V H L S L V P P A E E L Y Q Y L E T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Alternative names
Uncharacterized aarF domain-containing protein kinase 5, ADCK5
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Recombinant Human ADCK5 protein is a Human Fragment protein, in the 68 to 580 aa range, expressed in Baculovirus infected Sf9, with >75% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >75% SDS-PAGE
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q3MIX3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.307% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.001% PMSF
Sequence info
Amino acid sequence
- M A E A R E K R R M R L V V D G M G R F G R S L K V G L Q I S L D Y W W C T N V V L R G V E E N S P G Y L E V M S A C H Q R A A D A L V A G A I S N G G L Y V K L G Q G L C S F N H L L P P E Y T R T L R V L E D R A L K R G F Q E V D E L F L E D F Q A L P H E L F Q E F D Y Q P I A A A S L A Q V H R A K L H D G T S V A V K V Q Y I D L R D R F D G D I H T L E L L L R L V E V M H P S F G F S W V L Q D L K G T L A Q E L D F E N E G R N A E R C A R E L A H F P Y V V V P R V H W D K S S K R V L T A D F C A G C K V N D V E A I R S Q G L A V H D I A E K L I K A F A E Q I F Y T G F I H S D P H P G N V L V R K G P D G K A E L V L L D H G L Y Q F L E E K D R A A L C Q L W R A I I L R D D A A M R A H A A A L G V Q D Y L L F A E M L M Q R P V R L G Q L W G S H L L S R E E A A Y M V D M A R E R F E A V M A V L R E L P R P M L L V L R N I N T V R A I N V A L G A P V D R Y F L M A K R A V R G W S R L A G A T Y R G V Y G T S L L R H A K V V W E M L K F E V A L R L E T L A M R L T A L L A R A L V H L S L V P P A E E L Y Q Y L E T
- Accession
- Q3MIX3
- Protein length
- Fragment
- Predicted molecular weight
- 83 kDa
- Amino acids
- 68 to 580
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
Affinity purified.
General info
- Function
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
- Sequence similarities
Belongs to the protein kinase superfamily. ADCK protein kinase family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ADCK5 also known as aarF domain-containing kinase 5 is a protein kinase with a mass of around 66 kDa. This protein is involved in protein phosphorylation adding phosphate groups to specific substrates. Expression of ADCK5 occurs mainly in the inner membrane of mitochondria where it performs its functions. The protein possesses several domains characteristic of kinases facilitating its role in transferring phosphate groups within the cell. ADCK5 acts in concert with other kinases sharing structural similarities that clarify its kinase activity.
- Biological function summary
ADCK5 is involved in coenzyme Q biosynthesis an essential process for electron transport and ATP production in mitochondria. It forms part of a complex that includes several enzymes responsible for the multi-step synthesis of this coenzyme. ADCK5's proper function ensures the production of coenzyme Q which maintains mitochondrial integrity and energy metabolism. Disruption in ADCK5 activity can result in defects in mitochondrial function and cellular energy imbalance.
- Pathways
ADCK5 plays a role in the mitochondrial electron transport chain and oxidative phosphorylation. It interacts with other proteins such as COQ8A an essential participant in the same pathways. ADCK5 assists in the regulation and stabilization of the electron transport chain components contributing to efficient ATP production. The protein interconnects with other biochemical pathways emphasizing its significance in maintaining cellular energy homeostasis.
- Associated diseases and disorders
ADCK5 has been associated with coenzyme Q deficiency syndromes and mitochondrial disorders. Aberrant function of ADCK5 can lead to compromised mitochondrial function manifesting as muscle weakness or neurological impairments. The protein also connects to other mitochondrial proteins such as COQ9 in the context of these disorders suggesting a broader network of mitochondrial maintenance and health. Investigating ADCK5 could provide insight into therapeutic targets for correcting these deficiencies and improving mitochondrial performance.
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SDS-PAGE - Recombinant Human ADCK5 protein (ab191463)
SDS-PAGE of ADCK5 protein fragment (ab191463).
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