JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB191463

Recombinant Human ADCK5 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human ADCK5 protein is a Human Fragment protein, in the 68 to 580 aa range, expressed in Baculovirus infected Sf9 cells, with >75%, suitable for SDS-PAGE.

View Alternative Names

Uncharacterized aarF domain-containing protein kinase 5, ADCK5

1 Images
SDS-PAGE - Recombinant Human ADCK5 protein (AB191463)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ADCK5 protein (AB191463)

SDS-PAGE of ADCK5 protein fragment (ab191463).

Key facts

Purity

>75% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q3MIX3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.307% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.001% PMSF

storage-buffer

style
left-column

Complementary Products

Proteins & Peptides

AB219462

Recombinant Human Oligodendrocyte myelin glycoprotein (His tag)

SDS-PAGE - Recombinant Human Oligodendrocyte myelin glycoprotein (His tag) (AB219462)

  • 0
  • 0
Primary Antibodies

AB220914

Anti-COQ2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-COQ2 antibody (AB220914)

  • 0
  • 0
Proteins & Peptides

AB89485

Recombinant Human Estrogen Inducible Protein pS2

SDS-PAGE - Recombinant Human Estrogen Inducible Protein pS2 (AB89485)

  • 0
  • 0
Proteins & Peptides

AB191461

Recombinant Human ADCK3 protein

SDS-PAGE - Recombinant Human ADCK3 protein (AB191461)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAAYMVDMARERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGATYRGVYGTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLSLVPPAEELYQYLET","proteinLength":"Fragment","predictedMolecularWeight":"83 kDa","actualMolecularWeight":null,"aminoAcidEnd":580,"aminoAcidStart":68,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q3MIX3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADCK5 also known as aarF domain-containing kinase 5 is a protein kinase with a mass of around 66 kDa. This protein is involved in protein phosphorylation adding phosphate groups to specific substrates. Expression of ADCK5 occurs mainly in the inner membrane of mitochondria where it performs its functions. The protein possesses several domains characteristic of kinases facilitating its role in transferring phosphate groups within the cell. ADCK5 acts in concert with other kinases sharing structural similarities that clarify its kinase activity.
Biological function summary

ADCK5 is involved in coenzyme Q biosynthesis an essential process for electron transport and ATP production in mitochondria. It forms part of a complex that includes several enzymes responsible for the multi-step synthesis of this coenzyme. ADCK5's proper function ensures the production of coenzyme Q which maintains mitochondrial integrity and energy metabolism. Disruption in ADCK5 activity can result in defects in mitochondrial function and cellular energy imbalance.

Pathways

ADCK5 plays a role in the mitochondrial electron transport chain and oxidative phosphorylation. It interacts with other proteins such as COQ8A an essential participant in the same pathways. ADCK5 assists in the regulation and stabilization of the electron transport chain components contributing to efficient ATP production. The protein interconnects with other biochemical pathways emphasizing its significance in maintaining cellular energy homeostasis.

ADCK5 has been associated with coenzyme Q deficiency syndromes and mitochondrial disorders. Aberrant function of ADCK5 can lead to compromised mitochondrial function manifesting as muscle weakness or neurological impairments. The protein also connects to other mitochondrial proteins such as COQ9 in the context of these disorders suggesting a broader network of mitochondrial maintenance and health. Investigating ADCK5 could provide insight into therapeutic targets for correcting these deficiencies and improving mitochondrial performance.
style
left-column

Specifications

Form

Liquid

Additional notes

Affinity purified.

style
left-column

General info

Function

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family.

style
left-column

Product protocols

style
left-column

Target data

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
See full target information ADCK5
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com