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AB289766

Recombinant Human Adenosine A1 Receptor protein

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Recombinant Human Adenosine A1 Receptor protein is a Human Full Length protein, in the 1 to 326 aa range, expressed in Cell free, with >85%, suitable for SDS-PAGE.

View Alternative Names

Adenosine receptor A1, ADORA1

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SDS-PAGE - Recombinant Human Adenosine A1 Receptor protein (AB289766)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Adenosine A1 Receptor protein (AB289766)

SDS-PAGE analysis of ab289766

Key facts

Purity

>85% SDS-PAGE

Expression system

Cell free

Tags

10x His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P30542

Animal free

Yes

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% 2-Octadecoxyethanol

storage-buffer

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Complementary Products

Primary Antibodies

AB82477

Anti-Adenosine A1 Receptor antibody

BOND RX™ Validated

Western blot - Anti-Adenosine A1 Receptor antibody (AB82477)

  • 3
  • 2
Biochemicals

AB120440

NECA, adenosine agonist

Chemical Structure - NECA, adenosine agonist (AB120440)

  • 0
  • 0
Primary Antibodies

AB302891

Anti-PKC theta/PRKCQ antibody [27/PKC theta]

Recombinant|Trial Size

Immunoprecipitation - Anti-PKC theta/PRKCQ antibody [27/PKC theta] (AB302891)

  • 0
  • 0
Proteins & Peptides

AB126694

Recombinant Human Cyt 19 protein

SDS-PAGE - Recombinant Human Cyt 19 protein (AB126694)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD","proteinLength":"Full Length","predictedMolecularWeight":"39.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":326,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"P30542","tags":[{"tag":"10x His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Adenosine A1 Receptor also called A1 adenosine receptor is a G protein-coupled receptor (GPCR) with a mass of approximately 37 kDa. This receptor is primarily responsible for binding adenosine a nucleoside involved in numerous physiological processes. Mechanically the A1 receptor inhibits adenylyl cyclase activity via the Gi/o proteins resulting in decreased intracellular cyclic AMP levels. This receptor is expressed in various tissues including the brain heart and kidneys indicating its widespread physiological roles.
Biological function summary

The A1 receptor plays a significant role in mediating the inhibitory effects of adenosine on neurotransmitter release. It regulates synaptic transmission modulates excitability and protects tissues from excessive stimulation. This receptor does not function alone but is part of complex networks interacting with other proteins such as A2A receptors. A1 adenosine receptor signaling contributes to cardioprotection neuroprotection and regulation of renal blood flow reflecting its importance in maintaining homeostasis.

Pathways

The A1 receptor is essential in the adenosine signaling pathway and myocardial protection pathway. Through these pathways it influences important physiological responses like heart rate and blood flow. It interacts with proteins such as adenosine kinase and adenosine deaminase which regulate adenosine concentration influencing the availability of adenosine for receptor binding. The pathways involved illustrate the receptor's role in balancing energy supply and demand.

The A1 adenosine receptor is implicated in conditions like cardiac arrhythmias and epilepsy. Its role in reducing excitability and modulating synaptic transmission makes it a potential target for epilepsy treatment. In cardiac arrhythmias it helps regulate heart rate and protects against ischemic damage. The receptor's interactions with A2B receptors emphasize its role in complex disease mechanisms where it balances excitatory and inhibitory signals providing opportunities for therapeutic interventions.
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Specifications

Form

Lyophilized

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General info

Function

Receptor for adenosine (PubMed : 29925945). The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

Receptor for adenosine (PubMed : 29925945). The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase.
See full target information ADORA1
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Product promise

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