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AB219448

Recombinant Human ADH1C protein (His tag)

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Recombinant Human ADH1C protein (His tag) is a Human Full Length protein, in the 1 to 375 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

ADH3, ADH1C, Alcohol dehydrogenase 1C, Alcohol dehydrogenase subunit gamma

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SDS-PAGE - Recombinant Human ADH1C protein (His tag) (AB219448)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ADH1C protein (His tag) (AB219448)

15% SDS-PAGE analysis of ab219448 (3μg).

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P00326

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTFHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"40 kDa","actualMolecularWeight":null,"aminoAcidEnd":375,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"P00326","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ADH1C protein also known as alcohol dehydrogenase 1C plays an important role in the oxidation of alcohols to aldehydes and ketones. This enzyme features prominently in the metabolism of ethanol and other alcohols within the liver which is its primary expression site. ADH1C has a molecular mass of approximately 39 kDa and exists as a homodimer. This enzyme is part of a class of proteins responsible for breaking down alcohols utilizing NAD+ as a cofactor for their oxidizing reactions.
Biological function summary

Alcohol dehydrogenase 1C significantly influences the metabolism of alcohols in the liver. It contributes to the alcohol dehydrogenase complex which includes similar enzymes such as ADH1A and ADH1B. These enzymes work collaboratively to convert ethanol into acetaldehyde the first step in alcohol metabolism. ADH1C's activity affects the rate at which alcohol is processed impacting the accumulation of acetaldehyde which can be toxic in high concentrations.

Pathways

Alcohol dehydrogenase 1C plays a significant part in the ethanol metabolism pathway and the retinol metabolism pathway. In these pathways ADH1C interacts with other enzymes that facilitate the conversion of alcohols and retinoids into corresponding metabolites. ADH1C relates closely with aldehyde dehydrogenase proteins like ALDH2 which further processes acetaldehyde into acetate a less harmful substance. These pathways illustrate how ADH1C integrates into broader metabolic processes.

Alcohol dehydrogenase 1C shows relevance to alcohol-related liver disease and certain cancers. Variations in the ADH1C gene may influence an individual's susceptibility to liver damage from alcohol consumption. The connection between ADH1C acetaldehyde accumulation and disorders links it to ALDH2 whose deficiency enhances toxicity due to inefficient acetaldehyde breakdown. Understanding ADH1C's activity could allow for better risk assessments and therapeutic strategies aimed at alcohol-related health issues.
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Specifications

Form

Liquid

Additional notes

Affinity purified

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General info

Function

Alcohol dehydrogenase. Exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Product protocols

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Target data

Alcohol dehydrogenase. Exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism.
See full target information ADH1C
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