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AB126661

Recombinant Human ADH6 protein

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Recombinant Human ADH6 protein is a Human Full Length protein, in the 1 to 375 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Alcohol dehydrogenase 6, ADH6

1 Images
SDS-PAGE - Recombinant Human ADH6 protein (AB126661)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human ADH6 protein (AB126661)

15% SDS-PAGE analysis of 3µg of ab126661.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P28332

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMSTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLDLLYPTILGHEGAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQSKTQLMSDGTSRFTCKGKSIYHFGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFSTGFGAAINTAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIGVDVNKEKFKKAQELGATECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDVLAAALASCNESYGVCVVVGVLPASVQLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVADYMAEKLNLDPLITHTLNLDKINEAVELMKTGKCIRCILLL","proteinLength":"Full Length","predictedMolecularWeight":"42.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":375,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P28332","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADH6 also known as alcohol dehydrogenase 6 is an enzyme with an approximate molecular mass of 39 kDa. It belongs to the alcohol dehydrogenase family which plays an important role in the metabolism of alcohols and aldehydes. ADH6 has important catalytic activity and it oxidizes alcohol into aldehydes. This protein is expressed in various tissues within the human body including the liver which is essential for its metabolic functions.
Biological function summary

The enzyme ADH6 is involved in alcohol metabolism. It helps convert ethanol to acetaldehyde a process vital to energy extraction from alcohols. This conversion is part of the broader role that ADH6 plays in detoxifying alcohols and maintaining balance in alcohol and aldehyde levels. Researchers have not reported any complex formations involving ADH6 making it primarily a standalone enzyme within its metabolic processes.

Pathways

ADH6 is an important player in the alcohol dehydrogenase pathway and nucleotide metabolism. It collaborates with other alcohol dehydrogenase family members to manage the oxidation-reduction reactions concerning alcohols. The enzyme connects with proteins such as ADH1 and ADH4 which play roles in similar metabolic processes. Together they form part of a system that efficiently processes alcohol for energy production and detoxification.

ADH6 shows a relationship with conditions like alcohol dependence and liver disease. Variations in ADH6 activity can affect an individual's alcohol tolerance and risk for alcoholism. Additionally the protein's dysfunction can contribute to liver disease through improper alcohol metabolism. Other proteins like ALDH2 also interact within these pathways influencing diseases related to alcohol metabolism and detoxification processes.
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Specifications

Form

Liquid

Additional notes

ab126661 is purified using conventional chromatography techniques

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General info

Function

Alcohol dehydrogenase (PubMed : 1755855). Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes (PubMed : 1755855). Oxidizes secondary alcohols to the corresponding ketones (By similarity).

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily.

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Product protocols

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Target data

Alcohol dehydrogenase (PubMed : 1755855). Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes (PubMed : 1755855). Oxidizes secondary alcohols to the corresponding ketones (By similarity).
See full target information ADH6
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