Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein is a Human Full Length protein, in the 1 to 386 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
Amino acid sequence
M N E P T E N R L G C S R T P E P D I R L R K G H Q L D G T R R G D N D S H Q G D L E P I L E A S V L S S H H K K S S E E H E Y S D E A P Q E D E G F M G M S P L L Q A H H A M E K M E E F V C K V W E G R W R V I P H D V L P D W L K D N D F L L H G H R P P M P S F R A C F K S I F R I H T E T G N I W T H L L G C V F F L C L G I F Y M F R P N I S F V A P L Q E K V V F G L F F L G A I L C L S F S W L F H T V Y C H S E G V S R L F S K L D Y S G I A L L I M G S F V P W L Y Y S F Y C N P Q P C F I Y L I V I C V L G I A A I I V S Q W D M F A T P Q Y R G V R A G V F L G L G L S G I I P T L H Y V I S E G F L K A A T I G Q I G W L M L M A S L Y I T G A A L Y A A R I P E R F F P G K C D I W F H S H Q L F H I F V V A G A F V H F H G V S N L Q E F R F M I G G G C S E E D A L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).
Alternative names
Adiponectin receptor protein 2, Progestin and adipoQ receptor family member 2, Progestin and adipoQ receptor family member II, PAQR2, ADIPOR2
Recommended products
Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein is a Human Full Length protein, in the 1 to 386 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Alternative names
Adiponectin receptor protein 2, Progestin and adipoQ receptor family member 2, Progestin and adipoQ receptor family member II, PAQR2, ADIPOR2
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
- Accession
- Q86V24-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
M N E P T E N R L G C S R T P E P D I R L R K G H Q L D G T R R G D N D S H Q G D L E P I L E A S V L S S H H K K S S E E H E Y S D E A P Q E D E G F M G M S P L L Q A H H A M E K M E E F V C K V W E G R W R V I P H D V L P D W L K D N D F L L H G H R P P M P S F R A C F K S I F R I H T E T G N I W T H L L G C V F F L C L G I F Y M F R P N I S F V A P L Q E K V V F G L F F L G A I L C L S F S W L F H T V Y C H S E G V S R L F S K L D Y S G I A L L I M G S F V P W L Y Y S F Y C N P Q P C F I Y L I V I C V L G I A A I I V S Q W D M F A T P Q Y R G V R A G V F L G L G L S G I I P T L H Y V I S E G F L K A A T I G Q I G W L M L M A S L Y I T G A A L Y A A R I P E R F F P G K C D I W F H S H Q L F H I F V V A G A F V H F H G V S N L Q E F R F M I G G G C S E E D A L
- Accession
- Protein length
Full Length
- Amino acids
1 to 386
- Nature
Recombinant
- Tags
GST tag N-Terminus
Specifications
- Form
Liquid
General info
- Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).
- Sequence similarities
Belongs to the ADIPOR family.
Storage
- Shipped at conditions
Dry Ice
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
This product was previously labelled as Adiponectin Receptor 2.
Supplementary info
- Activity summary
Adiponectin Receptor 2 also known as ADIPOR2 or the adiponectin receptor is an integral membrane protein responsible for mediating the effects of adiponectin a hormone involved in regulating glucose and fatty acid metabolism. ADIPOR2 has a mass of about 39 kDa. It is predominantly expressed in skeletal muscle and liver tissues. The receptor plays a critical role in energy homeostasis and glucose regulation by binding to adiponectin which facilitates the activation of downstream signaling pathways.
- Biological function summary
ADIPOR2 influences energy balance and lipid metabolism. It is not part of a larger protein complex but functions in concert with another receptor Adiponectin Receptor 1 (ADIPOR1). The action of ADIPOR2 helps to enhance insulin sensitivity and fatty acid oxidation. The receptor also contributes to the regulation of metabolic rate and glucose uptake in the liver and muscle tissues supporting overall metabolic health.
- Pathways
ADIPOR2 connects to important metabolic routes such as the AMP-activated protein kinase (AMPK) pathway and the peroxisome proliferator-activated receptor alpha (PPARα) pathway. These pathways are important for cellular energy management and metabolic adaptation. ADIPOR2 cooperates with proteins like AMPK and PPARα to regulate lipid and glucose metabolism contributing to increased insulin sensitivity and efficient energy use in cells.
- Associated diseases and disorders
ADIPOR2 has links to conditions such as type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The receptor’s role in enhancing insulin sensitivity and promoting fatty acid oxidation makes it a significant target for understanding and potentially treating these metabolic disorders. Additionally its connection with proteins like AMPK suggests that manipulating ADIPOR2 activity could offer therapeutic benefits for managing insulin resistance and fatty liver-associated diseases.
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1 product image
SDS-PAGE - Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein (ab153509)
ab153509 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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