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AB153509

Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein (GST tag N-Terminus)

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Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 386 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

PAQR2, ADIPOR2, Adiponectin receptor protein 2, Progestin and adipoQ receptor family member 2, Progestin and adipoQ receptor family member II

1 Images
SDS-PAGE - Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein (GST tag N-Terminus) (AB153509)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein (GST tag N-Terminus) (AB153509)

ab153509 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q86V24

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB231051

Anti-Adiponectin Receptor 2/ADIPOR2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

  • 0
  • 0
Primary Antibodies

AB232928

Anti-Salusin alpha antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Salusin alpha antibody (AB232928)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB239579

Anti-Apolipoprotein A V/APOA5 antibody [C6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein A V/APOA5 antibody [C6] (AB239579)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Adiponectin Receptor 2.
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Sequence info

[{"sequence":"MNEPTENRLGCSRTPEPDIRLRKGHQLDGTRRGDNDSHQGDLEPILEASVLSSHHKKSSEEHEYSDEAPQEDEGFMGMSPLLQAHHAMEKMEEFVCKVWEGRWRVIPHDVLPDWLKDNDFLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGCVFFLCLGIFYMFRPNISFVAPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLDYSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFLGLGLSGIIPTLHYVISEGFLKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHIFVVAGAFVHFHGVSNLQEFRFMIGGGCSEEDAL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":386,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86V24","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Adiponectin Receptor 2 also known as ADIPOR2 or the adiponectin receptor is an integral membrane protein responsible for mediating the effects of adiponectin a hormone involved in regulating glucose and fatty acid metabolism. ADIPOR2 has a mass of about 39 kDa. It is predominantly expressed in skeletal muscle and liver tissues. The receptor plays a critical role in energy homeostasis and glucose regulation by binding to adiponectin which facilitates the activation of downstream signaling pathways.
Biological function summary

ADIPOR2 influences energy balance and lipid metabolism. It is not part of a larger protein complex but functions in concert with another receptor Adiponectin Receptor 1 (ADIPOR1). The action of ADIPOR2 helps to enhance insulin sensitivity and fatty acid oxidation. The receptor also contributes to the regulation of metabolic rate and glucose uptake in the liver and muscle tissues supporting overall metabolic health.

Pathways

ADIPOR2 connects to important metabolic routes such as the AMP-activated protein kinase (AMPK) pathway and the peroxisome proliferator-activated receptor alpha (PPARα) pathway. These pathways are important for cellular energy management and metabolic adaptation. ADIPOR2 cooperates with proteins like AMPK and PPARα to regulate lipid and glucose metabolism contributing to increased insulin sensitivity and efficient energy use in cells.

ADIPOR2 has links to conditions such as type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The receptor’s role in enhancing insulin sensitivity and promoting fatty acid oxidation makes it a significant target for understanding and potentially treating these metabolic disorders. Additionally its connection with proteins like AMPK suggests that manipulating ADIPOR2 activity could offer therapeutic benefits for managing insulin resistance and fatty liver-associated diseases.
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Specifications

Form

Liquid

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General info

Function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed : 12802337, PubMed : 25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

Sequence similarities

Belongs to the ADIPOR family.

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Product protocols

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Target data

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed : 12802337, PubMed : 25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).
See full target information ADIPOR2
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Product promise

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