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AB289733

Recombinant Human ADIPOR1 protein

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Recombinant Human ADIPOR1 protein is a Human Fragment protein, in the 89 to 375 aa range, expressed in Cell free, with >85%, suitable for SDS-PAGE.

View Alternative Names

PAQR1, TESBP1A, CGI-45, ADIPOR1, Adiponectin receptor protein 1, Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member I

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SDS-PAGE - Recombinant Human ADIPOR1 protein (AB289733)
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Supplier Data

SDS-PAGE - Recombinant Human ADIPOR1 protein (AB289733)

SDS-PAGE analysis of ab289733

Key facts

Purity

>85% SDS-PAGE

Expression system

Cell free

Tags

His-DDDDK tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96A54

Animal free

Yes

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.79% Sodium chloride, 0.14% Disodium hydrogenorthophosphate, 0.05% 2-Octadecoxyethanol, 0.024% Potassium phosphate monobasic, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"EGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDTLL","proteinLength":"Fragment","predictedMolecularWeight":"34.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":375,"aminoAcidStart":89,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q96A54","tags":[{"tag":"His-DDDDK","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Adiponectin receptor 1 (ADIPOR1) is a protein that mediates the effects of adiponectin a hormone involved in glucose regulation and fatty acid breakdown. ADIPOR1 is also known as the adiponectin receptor protein 1. It has a molecular weight of approximately 42 kDa. This receptor is widely expressed in various tissues including skeletal muscle liver pancreas and adipose tissue demonstrating its broad role in metabolism.
Biological function summary

ADIPOR1 facilitates the metabolic actions of adiponectin by increasing insulin sensitivity and promoting fatty acid oxidation. The receptor does not function alone; it operates in coordination with another isoform adiponectin receptor 2 (ADIPOR2) forming a complex to exert its full biological effects. This dual receptor system supports the regulation of energy homeostasis and inflammation influencing metabolic rate and improving lipid profiles.

Pathways

ADIPOR1 plays a critical role in the AMP-activated protein kinase (AMPK) pathway and the peroxisome proliferator-activated receptor alpha (PPAR-α) signaling pathway. These pathways are important for cellular energy balance and lipid metabolism. AMPK activation by ADIPOR1 leads to enhanced glucose uptake and fatty acid oxidation while interaction within the PPAR-α pathway regulates gene expression related to lipid metabolism. The activity of ADIPOR1 is intricately tied to other metabolic proteins like leptin and insulin thereby linking with these pathways.

ADIPOR1 involvement is significant in the development of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Its interaction with adiponectin and the modulation of insulin sensitivity positions it central to the pathophysiology of these conditions. These interactions highlight its potential as a therapeutic target. Disruption in ADIPOR1 function may influence related proteins such as adiponectin and insulin contributing to the progression of metabolic disorders.
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Specifications

Form

Lyophilized

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General info

Function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed : 12802337, PubMed : 25855295). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Sequence similarities

Belongs to the ADIPOR family.

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Product protocols

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Target data

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed : 12802337, PubMed : 25855295). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).
See full target information ADIPOR1
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Complementary Products

Primary Antibodies

AB70362

Anti-ADIPOR1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ADIPOR1 antibody (AB70362)

  • 3
  • 9
Proteins & Peptides

AB153509

Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein

SDS-PAGE - Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein (AB153509)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB231051

Anti-Adiponectin Receptor 2/ADIPOR2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

  • 0
  • 0

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