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AB276417

Recombinant Human Adrenomedullin/ADM protein (Fc Chimera)

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(1 Publication)

Recombinant Human Adrenomedullin/ADM protein (Fc Chimera) is a Human Fragment protein, in the 95 to 146 aa range, expressed in HEK 293 cells, with >93%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

AM, ADM, Pro-adrenomedullin

1 Images
SDS-PAGE - Recombinant Human Adrenomedullin/ADM protein (Fc Chimera) (AB276417)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Adrenomedullin/ADM protein (Fc Chimera) (AB276417)

SDS-PAGE analysis of ab276417

Key facts

Purity

>93% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P35318

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY","proteinLength":"Fragment","predictedMolecularWeight":"38 kDa","actualMolecularWeight":null,"aminoAcidEnd":146,"aminoAcidStart":95,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P35318","tags":[{"tag":"Fc","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The adrenomedullin (ADM) protein alternatively known as protein n20 is a peptide hormone with a mass of approximately 6 kilodaltons. It is mainly expressed in the adrenal medulla but you can also find it in various tissues including the heart lungs and kidneys. ADM is involved in multiple physiological processes operating as a vasodilator and playing a role in blood pressure regulation. The presence of ADM in endothelial and smooth muscle cells emphasizes its role in vascular function.
Biological function summary

Adrenomedullin contributes to homeostasis and cellular growth. It is not a part of a complex but interacts with specific receptors like the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs). These interactions activate signaling cascades that contribute to mitogenesis and angiogenesis highlighting ADM's role in cellular protection and tissue repair. ADM's activity extends to immune modulation and fluid-electrolyte balance.

Pathways

Adrenomedullin shows involvement in signaling pathways like the cAMP and MAPK pathways. It interacts closely with proteins such as RAMP2 and RAMP3 which define its receptor heterodimers in a tissue-dependent manner. ADM influences cellular responses by promoting vasodilation and modulating inflammatory responses fitting integrally into vascular homeostasis and immune functions.

ADM relates to cardiovascular and inflammatory diseases. It shows altered expression levels in conditions such as heart failure and sepsis. In these diseases ADM interacts with molecules like endothelin-1 which affect vascular tone and endothelial function. Understanding ADM's role can lead to potential therapeutic strategies targeting its pathways in cardiovascular and inflammatory pathologies.
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Specifications

Form

Lyophilized

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General info

Function

Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed : 8387282, PubMed : 9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.. Adrenomedullin. ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex.

Sequence similarities

Belongs to the adrenomedullin family.

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Product protocols

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Target data

Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed : 8387282, PubMed : 9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.. Adrenomedullin. ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex.
See full target information ADM
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Acta biomaterialia 145:146-158 PubMed35381399

2022

Nanoparticles with dense poly(ethylene glycol) coatings with near neutral charge are maximally transported across lymphatics and to the lymph nodes.

Applications

Unspecified application

Species

Unspecified reactive species

Jacob McCright,Colin Skeen,Jenny Yarmovsky,Katharina Maisel
View all publications
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