Recombinant Human ADTRP protein is a Human Full Length protein, in the 1 to 230 aa range, expressed in Cell free, with >=90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >=90% SDS-PAGE
- Expression system
- Cell free
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M T K T S T C I Y H F L V L S W Y T F L N Y Y I S Q E G K D E V K P K I L A N G A R W K Y M T L L N L L L Q T I F Y G V T C L D D V L K R T K G G K D I K F L T A F R D L L F T T L A F P V S T F V F L A F W I L F L Y N R D L I Y P K V L D T V I P V W L N H A M H T F I F P I T L A E V V L R P H S Y P S K K T G L T L L A A A S I A Y I S R I L W L Y F E T G T W V Y P V F A K L S L L G L A A F F S L S Y V F I A S I Y L L G E K L N H W K W G D M R Q P R K K R K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574).
Alternative names
C6orf105, ADTRP, Androgen-dependent TFPI-regulating protein, Fatty acid esters of hydroxy fatty acids hydrolase ADTRP, FAHFA hydrolase ADTRP
Recommended products
Recombinant Human ADTRP protein is a Human Full Length protein, in the 1 to 230 aa range, expressed in Cell free, with >=90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >=90% SDS-PAGE
- Expression system
- Cell free
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q96IZ2
- Animal free
- Yes
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4 - 8
Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% 2-Octadecoxyethanol
Sequence info
Amino acid sequence
- M T K T S T C I Y H F L V L S W Y T F L N Y Y I S Q E G K D E V K P K I L A N G A R W K Y M T L L N L L L Q T I F Y G V T C L D D V L K R T K G G K D I K F L T A F R D L L F T T L A F P V S T F V F L A F W I L F L Y N R D L I Y P K V L D T V I P V W L N H A M H T F I F P I T L A E V V L R P H S Y P S K K T G L T L L A A A S I A Y I S R I L W L Y F E T G T W V Y P V F A K L S L L G L A A F F S L S Y V F I A S I Y L L G E K L N H W K W G D M R Q P R K K R K
- Accession
- Q96IZ2
- Protein length
- Full Length
- Predicted molecular weight
- 31.8 kDa
- Amino acids
- 1 to 230
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574).
- Sequence similarities
Belongs to the AIG1 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ADTRP also known as androgen-dependent TFPI-regulating protein is a protein with a molecular mass of approximately 24 kDa. This protein is expressed in several tissues notably in human endothelium and heart. Mechanically ADTRP acts by modulating the activity of tissue factor pathway inhibitor (TFPI) which plays an important role in blood coagulation regulation. By influencing TFPI ADTRP controls hemostatic balance affecting both coagulation and fibrinolysis processes.
- Biological function summary
This protein is involved in maintaining vascular homeostasis. ADTRP does not act alone; it participates as part of a larger regulatory network impacting TFPI and coagulation pathways. The modulation of TFPI by ADTRP affects thrombin generation demonstrating its biological significance in controlling excessive blood clot formation therefore ensuring proper circulatory function and blood fluidity.
- Pathways
The activity of ADTRP is integral to the blood coagulation cascade. It connects closely with the extrinsic pathway of coagulation where it regulates the inhibitory action of TFPI on the factor Xa and thrombin generation. Another connection is with the fibrinolytic system where ADTRP influences the balance between clot formation and breakdown a critical aspect of vascular health.
- Associated diseases and disorders
ADTRP has implications in conditions like coronary artery disease and pulmonary embolism. Alterations in ADTRP's function can influence the balance between coagulation and anticoagulation impacting disease progression. As part of its role ADTRP is associated with other proteins involved in the coagulation pathway such as TFPI which is known to be a significant player in thrombotic conditions. Understanding how ADTRP connects to these diseases may offer pathways for therapeutic interventions.
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1 product image
SDS-PAGE - Recombinant Human ADTRP protein (ab289753)
SDS-PAGE analysis of ab289753
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