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AB289753

Recombinant Human ADTRP protein

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Recombinant Human ADTRP protein is a Human Full Length protein, in the 1 to 230 aa range, expressed in Cell free, with >90%, suitable for SDS-PAGE.

View Alternative Names

C6orf105, ADTRP, Androgen-dependent TFPI-regulating protein, Fatty acid esters of hydroxy fatty acids hydrolase ADTRP, FAHFA hydrolase ADTRP

1 Images
SDS-PAGE - Recombinant Human ADTRP protein (AB289753)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ADTRP protein (AB289753)

SDS-PAGE analysis of ab289753

Key facts

Purity

>90% SDS-PAGE

Expression system

Cell free

Tags

10x His tag N-Terminus Myc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96IZ2

Animal free

Yes

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% 2-Octadecoxyethanol

storage-buffer

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Complementary Products

Primary Antibodies

AB250593

Anti-MS4A14 antibody [EPR14020] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-MS4A14 antibody [EPR14020] - BSA and Azide free (AB250593)

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  • 0
Primary Antibodies

AB252931

Anti-CD229 antibody [EPR22611-91]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD229 antibody [EPR22611-91] (AB252931)

  • 5
  • 2
Primary Antibodies

AB36057

Anti-GLUT5 antibody

  • 0
  • 0
Primary Antibodies

AB305298

Anti-SIGLEC8 antibody [EPR24419-56] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-SIGLEC8 antibody [EPR24419-56] - BSA and Azide free (AB305298)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MTKTSTCIYHFLVLSWYTFLNYYISQEGKDEVKPKILANGARWKYMTLLNLLLQTIFYGVTCLDDVLKRTKGGKDIKFLTAFRDLLFTTLAFPVSTFVFLAFWILFLYNRDLIYPKVLDTVIPVWLNHAMHTFIFPITLAEVVLRPHSYPSKKTGLTLLAAASIAYISRILWLYFETGTWVYPVFAKLSLLGLAAFFSLSYVFIASIYLLGEKLNHWKWGDMRQPRKKRK","proteinLength":"Full Length","predictedMolecularWeight":"31.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":230,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q96IZ2","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADTRP also known as androgen-dependent TFPI-regulating protein is a protein with a molecular mass of approximately 24 kDa. This protein is expressed in several tissues notably in human endothelium and heart. Mechanically ADTRP acts by modulating the activity of tissue factor pathway inhibitor (TFPI) which plays an important role in blood coagulation regulation. By influencing TFPI ADTRP controls hemostatic balance affecting both coagulation and fibrinolysis processes.
Biological function summary

This protein is involved in maintaining vascular homeostasis. ADTRP does not act alone; it participates as part of a larger regulatory network impacting TFPI and coagulation pathways. The modulation of TFPI by ADTRP affects thrombin generation demonstrating its biological significance in controlling excessive blood clot formation therefore ensuring proper circulatory function and blood fluidity.

Pathways

The activity of ADTRP is integral to the blood coagulation cascade. It connects closely with the extrinsic pathway of coagulation where it regulates the inhibitory action of TFPI on the factor Xa and thrombin generation. Another connection is with the fibrinolytic system where ADTRP influences the balance between clot formation and breakdown a critical aspect of vascular health.

ADTRP has implications in conditions like coronary artery disease and pulmonary embolism. Alterations in ADTRP's function can influence the balance between coagulation and anticoagulation impacting disease progression. As part of its role ADTRP is associated with other proteins involved in the coagulation pathway such as TFPI which is known to be a significant player in thrombotic conditions. Understanding how ADTRP connects to these diseases may offer pathways for therapeutic interventions.
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Specifications

Form

Lyophilized

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General info

Function

Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed : 27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed : 27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed : 21868574).

Sequence similarities

Belongs to the AIG1 family.

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Product protocols

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Target data

Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed : 27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed : 27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed : 21868574).
See full target information ADTRP
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Product promise

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