JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB135022

Recombinant Human AEBP2 protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human AEBP2 protein (His tag N-Terminus) is a Human Full Length protein, in the 2 to 503 aa range, expressed in Baculovirus infected Sf9 cells, with >48%, suitable for SDS-PAGE.

View Alternative Names

Zinc finger protein AEBP2, Adipocyte enhancer-binding protein 2, AE-binding protein 2, AEBP2

1 Images
SDS-PAGE - Recombinant Human AEBP2 protein (His tag N-Terminus) (AB135022)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human AEBP2 protein (His tag N-Terminus) (AB135022)

4-20% SDS-PAGE analysis of ab135022 stained with Coomassie Blue.

Key facts

Purity

>48% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6ZN18

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl

storage-buffer

style
left-column

Complementary Products

Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Proteins & Peptides

AB271499

Recombinant human RbAp48+EED+SUZ12+AEBP2+EZH2 (mutated A738T) protein (Active)

Functional Studies - Recombinant human RbAp48+EED+SUZ12+AEBP2+EZH2 (mutated A738T) protein (Active) (AB271499)

  • 0
  • 0
Biochemicals

AB146152

UNC1999, EZH2 methyltransferase inhibitor

Chemical Structure - UNC1999, EZH2 methyltransferase inhibitor (AB146152)

  • 0
  • 0
Proteins & Peptides

AB198157

Recombinant human RBBP4 + EED + SUZ12 + EZH2 protein

Functional Studies - Recombinant human RBBP4 + EED + SUZ12 + EZH2 protein (AB198157)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"AAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKR","proteinLength":"Full Length","predictedMolecularWeight":"53.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":503,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q6ZN18","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AEBP2 also known as Adipocyte Enhancer-Binding Protein 2 is a zinc finger protein with a molecular weight of approximately 55 kDa. It is expressed in various tissues especially in the brain and adipose tissue. AEBP2 performs its function through its ability to bind DNA and interact with other proteins in the nucleus. This protein is involved in transcriptional regulation influencing gene expression by acting as a transcriptional repressor or activator depending on the context.
Biological function summary

AEBP2 plays an important role in chromatin remodeling as it is a part of the Polycomb Repressive Complex 2 (PRC2). This complex is essential for maintaining the transcriptionally repressive state of genes especially during development. By modulating histone methylation AEBP2 through PRC2 regulates the expression of genes important for cellular differentiation and proliferation. Its function is important for establishing the differentiation potential of stem cells and maintaining cellular identity.

Pathways

AEBP2 participates in significant biological routes such as the Wnt signaling and Hedgehog pathways. These pathways are responsible for regulating important aspects of embryonic development and cellular processes. Within the Wnt signaling pathway it interacts with other components like beta-catenin to regulate cell fate determination. In the Hedgehog pathway it has associations with proteins like GLI1 modulating gene expression linked to developmental patterning.

AEBP2 has connections with cancer and neurological disorders. Alterations in the expression levels of AEBP2 and the PRC2 complex have been linked with tumor progression especially in breast and prostate cancers. Dysfunction in its pathways also associates with neurodevelopmental disorders due to its role in gene silencing and methylation via PRC2. Proteins like EZH2 another component of PRC2 exhibit similar dysregulation in these disease contexts emphasizing the biological significance of AEBP2.
style
left-column

Specifications

Form

Liquid

Additional notes

Affinity purified.

style
left-column

General info

Function

Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed : 15225548, PubMed : 29499137, PubMed : 31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed : 29499137).

Sequence similarities

Belongs to the AEBP2/jing C2H2-type zinc-finger family.

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed : 15225548, PubMed : 29499137, PubMed : 31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed : 29499137).
See full target information Zinc finger protein AEBP2
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com