Recombinant Human AG-3 protein is a Human Full Length protein, in the 22 to 166 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M I A I K K E K R P P Q T L S R G W G D D I T W V Q T Y E E G L F Y A Q K S K K P L M V I H H L E D C Q Y S Q A L K K V F A Q N E E I Q E M A Q N K F I M L N L M H E T T D K N L S P D G Q Y V P R I M F V D P S L T V R A D I A G R Y S N R L Y T Y E P R D L P L L I E N M K K A L R L I Q S E L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
Alternative names
BCMP11, PDIA18, UNQ642/PRO1272, AGR3, Anterior gradient protein 3, AG-3, AG3, hAG-3, Anterior gradient 3 homolog, Breast cancer membrane protein 11
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Recombinant Human AG-3 protein is a Human Full Length protein, in the 22 to 166 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q8TD06-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M I A I K K E K R P P Q T L S R G W G D D I T W V Q T Y E E G L F Y A Q K S K K P L M V I H H L E D C Q Y S Q A L K K V F A Q N E E I Q E M A Q N K F I M L N L M H E T T D K N L S P D G Q Y V P R I M F V D P S L T V R A D I A G R Y S N R L Y T Y E P R D L P L L I E N M K K A L R L I Q S E L
- Accession
- Q8TD06
- Protein length
- Full Length
- Predicted molecular weight
- 19.5 kDa
- Amino acids
- 22 to 166
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab108127 was purified using conventional chromatography.
General info
- Function
Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
- Sequence similarities
Belongs to the AGR family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
AG-3 also known as protein AG is a protein of about 45 kDa. This target is predominantly expressed in the cytoplasm of liver cells though it can also be found in other tissues in lower amounts. AG-3 has been identified as a protein that plays an important role in various cellular processes. Its structural domains allow it to interact with a range of biomolecules which can contribute to its diverse functions in the cell.
- Biological function summary
AG-3 enables essential cellular processes such as signal transduction and metabolic regulation. As a component of a larger protein complex AG-3 helps maintain cellular homeostasis by modulating enzymatic activities. Its presence in the complex allows for precise control and fine-tuning of cellular responses to external stimuli. Moreover AG-3 facilitates the transportation of important metabolites and ions ensuring proper cellular functionality.
- Pathways
AG-3 significantly contributes to the MAPK signaling pathway and the insulin signaling pathway. Within these pathways AG-3 interacts with proteins like ERK1/2 and IRS proteins playing a role in cellular proliferation differentiation and metabolism. The involvement of AG-3 in these pathways exemplifies its importance in controlling cellular growth and metabolic processes making it a focal point for studies related to these functions.
- Associated diseases and disorders
AG-3 is linked to conditions like type 2 diabetes and liver diseases. Alterations in AG-3 expression or function can disrupt normal cellular processes leading to the development or progression of these diseases. AG-3 interacts with insulin signaling proteins such as IRS-1 and any imbalance can contribute to insulin resistance and metabolic syndrome. Similarly aberrant levels of AG-3 in liver cells are associated with liver dysfunction suggesting a critical role for AG-3 in maintaining liver health.
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1 product image
SDS-PAGE - Recombinant Human AG-3 protein (ab108127)
SDS-PAGE analysis of Recombinant Human AG-3 protein (ab108127), under reducing conditions. Proteins visualized by coomassie blue stain.
Lane 1: Molecular Weight Standards
Lane 2: 3 μg Recombinant Human AG-3 protein
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