JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB163064

Recombinant Human AGPAT5 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human AGPAT5 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 364 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon, 1-acylglycerol-3-phosphate O-acyltransferase 5, Lysophosphatidic acid acyltransferase epsilon, 1-AGP acyltransferase 5, 1-AGPAT 5, LPAAT-epsilon, AGPAT5

1 Images
SDS-PAGE - Recombinant Human AGPAT5 protein (GST tag N-Terminus) (AB163064)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human AGPAT5 protein (GST tag N-Terminus) (AB163064)

ab163064 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9NUQ2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Complementary Products

Proteins & Peptides

AB165455

Recombinant Human ZNF358 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZNF358 protein (GST tag N-Terminus) (AB165455)

  • 0
  • 0
Proteins & Peptides

AB165467

Recombinant Human ZBTB46 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZBTB46 protein (GST tag N-Terminus) (AB165467)

  • 0
  • 0
Proteins & Peptides

AB165841

Recombinant Human UBR1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human UBR1 protein (GST tag N-Terminus) (AB165841)

  • 0
  • 0
Proteins & Peptides

AB202146

Recombinant Human TBC1D22B protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human TBC1D22B protein (AB202146)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MLLSLVLHTYSMRYLLPSVVLLGTAPTYVLAWGVWRLLSAFLPARFYQALDDRLYCVYQSMVLFFFENYTGVQILLYGDLPKNKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTPMYLVIFPEGTRYNPEQTKVLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVVYEGKDDGGQRRESPTMTEFLCKECPKIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYESPDPERRKRFPGKSVNSKLSIKKTLPSMLILSGLTAGMLMTDAGRKLYVNTWIYGTLLGCLWVTIKA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":364,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NUQ2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AGPAT5 also known as 1-acylglycerol-3-phosphate O-acyltransferase 5 is an enzyme involved in lipid metabolism. It has a mass of approximately 47 kDa. AGPAT5 catalyzes the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA) by adding an acyl group. This enzyme is expressed in various tissues with higher levels in adipose tissue and liver. Despite its wide expression its specific regulation mechanisms remain under investigation.
Biological function summary

AGPAT5 plays a role in the biosynthesis of phospholipids and triglycerides. It is not commonly part of a large protein complex but it contributes significantly to the synthesis of important lipid molecules. These molecules are important for cell membrane formation and energy storage. AGPAT5 activity influences cellular lipid composition impacting membrane fluidity and cell signaling.

Pathways

The enzyme AGPAT5 functions within the glycerolipid metabolism pathway. It interacts directly with intermediates like lysophosphatidic acid and phosphatidic acid which are key molecules in this pathway. The enzyme also links to the phosphatidic acid biosynthesis pathway sharing functional similarities with other AGPAT family members such as AGPAT1. These interactions highlight its role in maintaining cellular lipid balance.

AGPAT5 has associations with metabolic conditions like obesity and type 2 diabetes. Changes in lipid metabolism mediated by AGPAT5 can lead to altered adipose tissue function. Through its effects on lipid pathways AGPAT5 has indirect connections with other metabolic dysregulation proteins such as hormone-sensitive lipase (HSL). Further research into AGPAT5 could provide insights into therapeutic targets for these metabolic disorders.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed : 21173190). Acts on LPA containing saturated or unsaturated fatty acids C15 : 0-C20 : 4 at the sn-1 position using C18 : 1-CoA as the acyl donor (PubMed : 21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed : 21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed : 21173190).

Sequence similarities

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Subcellular localisation

Nucleus envelope

style
left-column

Product protocols

style
left-column

Target data

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed : 21173190). Acts on LPA containing saturated or unsaturated fatty acids C15 : 0-C20 : 4 at the sn-1 position using C18 : 1-CoA as the acyl donor (PubMed : 21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed : 21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed : 21173190).
See full target information AGPAT5
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com