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AB187446

Recombinant Human AGPHD1 protein (His tag N-Terminus)

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Recombinant Human AGPHD1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 373 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

AGPHD1, HYKK, Hydroxylysine kinase, 5-hydroxy-L-lysine kinase, Aminoglycoside phosphotransferase domain-containing protein 1

1 Images
SDS-PAGE - Recombinant Human AGPHD1 protein (His tag N-Terminus) (AB187446)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human AGPHD1 protein (His tag N-Terminus) (AB187446)

15% SDS-PAGE (ab187446 at 3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

A2RU49

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSSGNYQQSEALSKPTFSEEQASALVESVFGLKVSKVRPLPSYDDQNFHVYVSKTKDGPTEYVLKISNTKASKNPDLIEVQNHIIMFLKAAGFPTASVCHTKGDNTASLVSVDSGSEIKSYLVRLLTYLPGRPIAELPVSPQLLYEIGKLAAKLDKTLQRFHHPKLSSLHRENFIWNLKNVPLLEKYLYALGQNRNREIVEHVIHLFKEEVMTKLSHFRECINHGDLNDHNILIESSKSASGNAEYQVSGILDFGDMSYGYYVFEVAITIMYMMIESKSPIQVGGHVLAGFESITPLTAVEKGALFLLVCSRFCQSLVMAAYSCQLYPENKDYLMVTAKTGWKHLQQMFDMGQKAVEEIWFETAKSYESGIS","proteinLength":"Full Length","predictedMolecularWeight":"44.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":373,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"A2RU49","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AGPHD1 also known as alkylglycerol monooxygenase is an enzyme with an approximate molecular mass of 31 kDa. Mechanically it functions as a dioxygenase that catalyzes the initial hydroxylation step in the breakdown of alkylglycerols. Throughout the body AGPHD1 shows expression in tissues that are rich in lipids such as the liver and adrenal glands.
Biological function summary

The enzyme participates in the degradation of ether lipids a class of lipids significant for cellular messaging and membrane structure. AGPHD1 does not seem to function as part of a larger protein complex but it plays an important role in maintaining the balance of ether-linked lipids in cell membranes and within lipid metabolism.

Pathways

AGPHD1 intersects with several lipid metabolism pathways and notably affects peroxisomal ether lipid metabolism. It interacts indirectly with proteins like peroxin which manage peroxisome function important for cellular detoxification processes and fat metabolism regulation.

AGPHD1's imbalance or dysfunction is linked to lipid storage disorders and certain metabolic syndromes. Aberrations in its activity can influence related proteins such as those involved in the peroxisome biogenesis which may contribute to conditions like Zellweger syndrome where normal lipid breakdown and cellular metabolism are disrupted.
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Specifications

Form

Liquid

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General info

Function

Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

Sequence similarities

Belongs to the aminoglycoside phosphotransferase family.

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Product protocols

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Target data

Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
See full target information HYKK
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