Recombinant Human AHRR protein is a Human Fragment protein, in the 617 to 715 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
R A T A G R S R E L T P F H P A H C A C L E P T D G L P Q S E P P H Q L C A R G R G E Q S C T C R A A E A A P V V K R E P L D S P Q W A T H S Q G M V P G M L P K S A L A T L V P P Q A S G C T F L P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Alternative names
BHLHE77, KIAA1234, AHRR, Aryl hydrocarbon receptor repressor, AhR repressor, AhRR, Class E basic helix-loop-helix protein 77, bHLHe77
Recommended products
Recombinant Human AHRR protein is a Human Fragment protein, in the 617 to 715 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- A9YTQ3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- R A T A G R S R E L T P F H P A H C A C L E P T D G L P Q S E P P H Q L C A R G R G E Q S C T C R A A E A A P V V K R E P L D S P Q W A T H S Q G M V P G M L P K S A L A T L V P P Q A S G C T F L P
- Accession
- A9YTQ3
- Protein length
- Fragment
- Amino acids
- 617 to 715
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The aryl hydrocarbon receptor repressor (AHRR) is a protein that functions by inhibiting the activity of the aryl hydrocarbon receptor (AHR). It achieves this by competing with AHR for binding to AHR nuclear translocator (ARNT) forming a complex that prevents AHR from activating its target genes. AHRR weighs approximately 78 kDa and is expressed in various tissues particularly in those with a high exposure to environmental toxins such as the liver and lungs. This expression pattern suggests its role in modulating responses to external chemicals.
- Biological function summary
AHRR is essential in regulating gene expression involved in responses to xenobiotics. It is part of the AHR signaling complex functioning as a feedback inhibitor that controls the extent and duration of AHR-mediated transcriptional activity. By doing so AHRR helps maintain cellular homeostasis and protects against potential harmful effects of excessive activation of AHR pathways. It also influences the differentiation and function of immune cells and has roles in development and metabolism.
- Pathways
AHRR is integral in the xenobiotic metabolism and dioxin signaling pathways. These pathways involve the detoxification processes of harmful compounds. AHRR interacts with proteins like AHR and ARNT to modulate these pathways ensuring that cells respond correctly to environmental pollutants. Through these interactions AHRR also influences the balance of cellular proliferation and apoptosis acting to maintain physiological functions and prevent toxicity.
- Associated diseases and disorders
AHRR has associations with cancer and autoimmune diseases. Dysregulation of AHRR expression can lead to increased susceptibility to cancers as AHR activity becomes unchecked promoting tumor growth and progression. Additionally aberrant AHRR function is linked with autoimmune disorders due to its role in controlling immune system activities. AHRR interacts closely with AHR and ARNT in these disease contexts highlighting the importance of its regulatory functions in maintaining health.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human AHRR protein (ab153451)
ab153451 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com