JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB140560

Recombinant Human AIDA protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human AIDA protein is a Human Full Length protein, in the 1 to 306 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C1orf80, AIDA, Axin interaction partner and dorsalization antagonist

1 Images
SDS-PAGE - Recombinant Human AIDA protein (AB140560)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human AIDA protein (AB140560)

15% SDS-PAGE analysis of 3 µg ab140560.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q96BJ3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSEVTRSLLQRWGASFRRGADFDSWGQLVEAIDEYQILARHLQKEAQAQHNNSEFTEEQKKTIGKIATCLELRSAALQSTQSQEEFKLEDLKKLEPILKNILTYNKEFPFDVQPVPLRRILAPGEEENLEFEEDEEEGGAGAGSPDSFPARVPGTLLPRLPSEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYVHFNVDIELQKHVEKLTKGAAIFFEFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIELYKKPTDFKRKKLQLLTKKPLYLHLHQTLHKE","proteinLength":"Full Length","predictedMolecularWeight":"37.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":306,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96BJ3","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The AIDA protein also known as Anisomycin-induced protein A is a little-studied member of a protein family yet plays significant mechanical roles in cellular activities. Its molecular mass is not well characterized but researchers have noted its expression across various tissues notably in the brain and immune cells. The presence in these tissues suggests a versatile and potentially significant function in cellular processes awaiting further exploration.
Biological function summary

The AIDA protein interacts with multiple cellular components to modulate immune responses. It likely forms part of a multi-protein complex orchestrating signaling processes pivotal for cell communication and response. The protein appears to regulate the transcription of certain genes implicated in stress responses offering insights into its possible regulatory roles within cells.

Pathways

AIDA is integrated into the MAPK signaling pathway which is important for transmitting cellular responses to stress stimuli. AIDA interacts with other proteins such as ERK and JNK within this pathway demonstrating its involvement in modulating cellular reactions to external stimuli. This association highlights the dynamic role of AIDA in adapting cellular states to environmental conditions.

AIDA's function relates significantly to neuroinflammatory conditions and immune dysregulation. Its interaction with proteins like NF-kB suggests a role in pathogenesis where chronic inflammation is prevalent such as in multiple sclerosis and rheumatoid arthritis. These associations emphasize the potential of AIDA as a target for therapeutic interventions in inflammatory diseases promising advances for treatment strategies.
style
left-column

Specifications

Form

Liquid

Additional notes

ab140560 was purified using conventional chromatography.

style
left-column

General info

Function

Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).

Sequence similarities

Belongs to the AIDA family.

style
left-column

Product protocols

style
left-column

Target data

Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).
See full target information AIDA
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB139251

Recombinant Human AICDA protein (denatured)

SDS-PAGE - Recombinant Human AICDA protein (denatured) (AB139251)

  • 0
  • 0
Primary Antibodies

AB274421

Anti-AIDA antibody [EPR20903-53] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Western blot - Anti-AIDA antibody [EPR20903-53] - BSA and Azide free (AB274421)

  • 0
  • 0
Proteins & Peptides

AB156351

Recombinant Human Ephrin A3 protein (denatured)

SDS-PAGE - Recombinant Human Ephrin A3 protein (denatured) (AB156351)

  • 0
  • 0
Proteins & Peptides

AB60838

Recombinant human PRKACG protein

Functional Studies - Recombinant human PRKACG protein (AB60838)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com