Recombinant Human AIF1L protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AIF1L also known as Allograft Inflammatory Factor 1-like is a protein with a molecular weight of approximately 17 kDa. It's mainly expressed in activated macrophages and microglia. AIF1L is also detected in several other tissues such as the spleen pancreas and small intestine. In cells it localizes to the cytoplasm and sometimes the nucleus contributing to cytoskeletal organization.

Biological function summary

The protein functions in immune response modulation and cellular activation processes. It does not form part of a known protein complex but it contributes significantly to actin cytoskeleton rearrangement suggesting a role in cell migration and phagocytosis. AIF1L influences inflammatory responses by modulating macrophage activity which is important for tissue injury response and repair processes.

Pathways

AIF1L interacts with cytoskeletal signaling pathways and immune system pathways. AIF1L's role in actin rearrangement links it to pathways involved in cellular motility and structural integrity. Its modulation of inflammation connects it to pathway interactions with other proteins like actin-binding proteins and cytokines influencing immune system regulation and macrophage activation.

AIF1L holds relevance to autoimmunity and atherosclerosis where immune response regulation is disrupted. In autoimmune conditions the dysregulation of pathways involving AIF1L can exacerbate immune cell activation and inflammation. In atherosclerosis its function in macrophage activation intersects with proteins like CD68 contributing to foam cell formation and plaque buildup in arterial walls advancing our understanding of inflammatory processes in cardiovascular diseases.