Recombinant Human AIP protein is a Human Full Length protein, in the 1 to 330 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H P V W E T I V C T M R E G E I A Q F L C D I K H V V L Y P L V A K S L R N I A V G K D P L E G Q R H C C G V A Q M R E H S S L G H A D L D A L Q Q N P Q P L I F H M E M L K V E S P G T Y Q Q D P W A M T D E E K A K A V P L I H Q E G N R L Y R E G H V K E A A A K Y Y D A I A C L K N L Q M K E Q P G S P E W I Q L D K Q I T P L L L N Y C Q C K L V V E E Y Y E V M A D I I A R L R E D G I Q K R V I Q E G R G E L P D F Q D G T K A T F H Y R T L H S D D E G T V L D D S R A R G K P M E L I I G K K F K L L D H C S S I L N K Y D D N V K A Y F K R G K A H A A V W N A Q E A Q A D F A K V L E L D P A L A P V V S R E L R A L E A R I R Q K D E E D K A R F R G I F S H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Cellular negative regulator of the hepatitis B virus (HBV) X protein.
Alternative names
XAP2, AIP, AH receptor-interacting protein, Aryl-hydrocarbon receptor-interacting protein, HBV X-associated protein 2, Immunophilin homolog ARA9, XAP-2
Recommended products
Recombinant Human AIP protein is a Human Full Length protein, in the 1 to 330 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- O00170-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H P V W E T I V C T M R E G E I A Q F L C D I K H V V L Y P L V A K S L R N I A V G K D P L E G Q R H C C G V A Q M R E H S S L G H A D L D A L Q Q N P Q P L I F H M E M L K V E S P G T Y Q Q D P W A M T D E E K A K A V P L I H Q E G N R L Y R E G H V K E A A A K Y Y D A I A C L K N L Q M K E Q P G S P E W I Q L D K Q I T P L L L N Y C Q C K L V V E E Y Y E V M A D I I A R L R E D G I Q K R V I Q E G R G E L P D F Q D G T K A T F H Y R T L H S D D E G T V L D D S R A R G K P M E L I I G K K F K L L D H C S S I L N K Y D D N V K A Y F K R G K A H A A V W N A Q E A Q A D F A K V L E L D P A L A P V V S R E L R A L E A R I R Q K D E E D K A R F R G I F S H
- Accession
- O00170
- Protein length
- Full Length
- Predicted molecular weight
- 39.8 kDa
- Amino acids
- 1 to 330
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab109934 is purified using conventional chromatography techniques.
General info
- Function
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
AIP also known as aryl hydrocarbon receptor-interacting protein is a molecular chaperone with a mass of approximately 37 kDa. It mainly resides in the cytoplasm of cells and interacts with various proteins. Expression of the AIP protein occurs in many tissues including liver lung and brain. This protein plays a significant role in maintaining the stability and proper functioning of its interacting partners.
- Biological function summary
AIP acts as a modulator of protein-protein interactions impacting several signaling pathways. It is a part of the larger protein complex involving heat shock proteins which helps prevent the degradation of its client proteins. AIP is essential for the activity and stability of receptors like the aryl hydrocarbon receptor (AHR) helping these receptors remain in a functional state until they get activated.
- Pathways
AIP incorporates itself into the AHR signaling pathway which affects the regulation of xenobiotic metabolism. The protein is also involved in the regulation of the glucocorticoid receptor pathway working closely with proteins like Hsp90. Through these interactions AIP influences the ability of cells to respond to environmental toxins and physiological stress thereby playing a role in cellular homeostasis.
- Associated diseases and disorders
AIP has a connection with familial isolated pituitary adenomas (FIPA) and is also implicated in some forms of cancer. AIP mutations can lead to alterations in the function of the AHR receptor which is linked to these conditions. A notable interaction partner of AIP in these contexts is the pituitary tumor transforming gene (PTTG) which highlights its role in tumorigenesis and the regulation of cell proliferation.
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1 product image
SDS-PAGE - Recombinant Human AIP protein (ab109934)
15% SDS-PAGE showing ab109934 at approximately 39.8 kDa (3µg).
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