Recombinant Human AK6 protein
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Recombinant Human AK6 protein is a Human Full Length protein, in the 1 to 172 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
CINAP, AD-004, CGI-137, AK6, Adenylate kinase isoenzyme 6, Adrenal gland protein AD-004, Coilin-interacting nuclear ATPase protein, Dual activity adenylate kinase/ATPase, hCINAP, AK/ATPase
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human AK6 protein (AB104633)
15% SDS-PAGE showing ab104633 (3 μg) at approximately 22.2 kDa. (Molecular weight on SDS-PAGE will appear higher).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
AK6 contributes to the cellular energy balance and is involved in nucleotide metabolism. It does not form part of large protein complexes acting instead through its enzymatic activity within individual cells. It modulates levels of ADP ATP and AMP which is important for processes that harness or require energy. By regulating these nucleotides AK6 influences muscle contraction cell proliferation and apoptosis.
Pathways
AK6 functions within the purine metabolism pathway and is an integral component of the energy metabolism pathway. It interacts with other adenylate kinases such as AK2 to manage the equilibrium of adenine nucleotides in cells. Its activity directly impacts the balance and flow of energy resources linking it to pathways that oversee energy transduction and cellular metabolic regulation.
Specifications
Form
Liquid
Additional notes
ab104633 is purified using conventional chromatography techniques.
General info
Function
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity (PubMed : 15630091). Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation (PubMed : 27477389). While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit (By similarity). Its NMP activity may have a role in nuclear energy homeostasis. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May be involved in regulation of Cajal body (CB) formation (PubMed : 15630091).
Sequence similarities
Belongs to the adenylate kinase family. AK6 subfamily.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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