Recombinant Human AKAP7 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AKAP7 also known as A-kinase anchoring protein 7 plays a vital role in cellular signaling by binding to protein kinase A (PKA) and anchoring it to specific cellular compartments. This protein has a molecular weight of approximately 53 kDa. AKAP7 is expressed in various tissues with notable expression in the brain and heart indicating its involvement in significant physiological processes. It acts through its function as an anchoring protein facilitating the localization of protein kinase A which is necessary for proper signal transduction.

Biological function summary

AKAP7 functions by organizing PKA and other signaling molecules into complexes that ensure efficient signal relay. By anchoring PKA to specific subcellular locations AKAP7 regulates the access of PKA to its substrates. This organization is part of larger multi-protein complexes that maintain efficient signal specificity and strength. Disruption of AKAP7's ability to form these complexes may lead to altered signaling pathways impacting normal cellular function.

Pathways

AKAP7 integrates into the cAMP signaling pathway which is essential for regulating intracellular levels of cyclic AMP. This involvement affects diverse processes such as metabolism gene transcription and muscle contraction. AKAP7 interacts closely with protein kinase C (PKC) within these pathways illustrating the protein's ability to coordinate different signaling molecules. It ensures the spatial and temporal precision of cellular responses to external stimuli by guiding the activity of PKA.

Alterations in AKAP7 expression or function link to cardiac arrhythmias and Alzheimer's disease. In cardiac arrhythmias AKAP7's role in anchoring PKA impacts heart muscle contraction and electrical activity. Its interaction with other proteins such as Gi-protein and ion channels can modify cardiac rhythm. In Alzheimer's disease AKAP7 may influence pathological processes by affecting signaling pathways involved in neuronal communication. Understanding AKAP7's connection to these diseases provides insight into potential therapeutic targets for modulation.